胃泌素和微小RNA与大肠癌的发生发展

Gastrin and miRNA in the development of colorectal neoplasms

已证实某些大肠癌中胃泌素能高表达并通过其受体介导的信号转导通路促进细胞增殖且抑制凋亡。微小RNA（miRNA）参与大肠癌相关基因表达调控，研究表明miRNA在大肠癌中的调控网络与胃泌素促大肠癌增殖信号通路存在多个交叉点，提示在胃泌素促大肠癌细胞增殖过程中可能存在一类新的胃泌素-miRNA信号通路，有望为大肠癌的诊断和分子靶向治疗寻找到一个新的切人途径。

It has been reported that the high expression of gastrins and their receptors promotes some colorectal neoplasms cells proliferation and inhibit apoptosis. MieroRNAs（miRNAs） are closely related to gene expression regulation in eoloreetal neoplasms. Researches show that miRNAs have multiple intersections in the regulatory network of colorectal neoplasms with the signal transduction pathway of gatrins which controls the pro- liferation of colorectal neoplasms. Gastrins perhaps control the proliferation of colorectal neoplasms cells through miRNA signal transduction pathways. These findings have greatly expanded the understanding of the pathoge nesis of colorectal neoplasms and will provide new ideas and methods for the diagnosis and treatment of eolorectal neoplasms.