氧化应激与支气管哮喘气道黏液高分泌研究进展

Oxidative stress and airway mucus hypersecretion

哮喘是一种以支气管收缩可逆性、肺部炎症及气道重塑为特点的慢性气道炎症性疾病。黏液过度分泌导致气道阻塞、肺功能下降、气道重塑和感染增加。过度的活性氧／活性氮（ROS／RNS）产生造成气道炎症，气道高反应性，气道微血管高通透性和气道黏液高分泌，以及组织损伤和形态的改变。减轻氧化应激或增加抗氧化能够减轻气道嗜酸粒细胞，减少黏液分泌，减轻支气管高反应性。本文就氧化应激与哮喘气道黏液高分泌的关系作一综述。

Asthma is a bronchoconstriction reversibility, lung in{lammation and airway remodeling for characteristics of chronic airway inflammatory disease. Excessive mucus secretion lead to obstruction of the airway, lung function decline, airway remodeling and increase infection. Excessive reactive oxygen species/reactive nitrogen species （ROS/RNS） produce cause airway inflammation, airway responsieness, airway microvascular high permeability and high airway mucus secretion, and tissue damage and the change of the form. Reduce oxidative stress or increase antioxidant that can reduce airway eosinophils, reduce mucus secretion, reduce bronchial high reaction. Oxidative stress and asthma airway mucus secretion relationship high application were introduced in this paper.