重症甲型H1N1流感24例临床研究

Clincal research of 24 patients with severe influenza A(H1N1)

目的探讨危重型甲型H1N1流感的临床特征。方法对阜阳市第二人民医院2009年11月至2010年4月收治的24例危重型甲型H1N1流感患者的临床资料进行回顾性分析。结果所有患者均为19～35岁孕妇,早期有流感症状,临床表现以急性呼吸窘迫综合征为主的全身多器官功能障碍,病情危重期出现在病程第3～5天,治疗上采取了以机械通气为主的综合性措施。20例治愈,4例因呼吸循环衰竭死亡。结论甲型H1N1流感是一种新发的致命性传染病。妊娠期妇女是甲型流感的高危人群,易发展成为重型病例,且预后不良。早诊断、早期抗病毒、适时终止妊娠、适时进行机械通气辅助呼吸可改善患者预后。

Objective To investigate the clinical features of patients with severe influenza A（ H1N1 ）. Methods The clini- cal data of 24 patients with severe influenza A （ H1N1 ） virus from November 2009 to April 2010 in the second people＇ s hospital of Fuyang were retrospectively analyzed. Results All the patients were 19 - 35 years old young pregnant women. In the early days, all of them had flu-like symptoms. The critical condition appears in the first 3 - 5 days, clinical manifestation was acute re- spiratory distress syndrome-based multi-systemic organ dysfunction, mechanical ventilation based comprehensive measures were given. After treatment, 20 cases were cured, 4 cases died of respiratory and circulatory failure. Conclusion Influenza A （H1N1） is a new lethal infectious diseases. Pregnant women are at high risk of H1N1, they are easy to develop into critical ca- ses, and have poor prognosis. Early diagnosis, early anti-virus, timely termination of pregnancy and mechanical ventilation can improve the prognosis of the patients.