甲泼尼龙联合氨茶碱治疗急性期支气管哮喘的效果分析

Analysis of Efficacy on Acute Stage of Bronchial Asthma Treatment

目的探讨甲泼尼龙联合氨茶碱治疗急性期支气管哮喘的临床效果和安全性。方法将96例支气管哮喘确诊患者随机分为观察组（50例）和对照组（46例），所有患者均行常规对症支持治疗，在此基础上观察组加用氨茶碱和甲泼尼龙，对照组加用氨茶碱，观察并记录两组治疗效果、起效时间及并发症发生情况。结果观察组治疗总有效率（98．0％）明显高于对照组（73．9％）（P〈0．05），起效时间[（7．3±0．5）h]明显短于对照组[（14．7±2．1）h]（P〈0．05），并发症发生率（8．0％）明显低于对照组（17．4％）（P〈0．05）。结论在采用常规对症支持治疗的基础上加用甲泼尼龙和氨茶碱治疗支气管哮喘急性期患者起效快，疗效确切，安全性好，值得临床推广。

Objective To study the efficacy and safety of treatment with methylprednisolone for stageof bronchial asthma. Methods 96 patients diagnosed as bronchial asthma were divided into observation group （ 50 cases） and control group（46 cases）. All the patients were treated with conventional expectant and supporting treat- ment, and aminophylline and methylprednisolone were added in observation group, while only aminophylline was added in control group. The efficacy, onset time and the incidence of complications were recorded. Results The total effec- tive rate in observation group was higher than that in control group （98.0% vs 73.9% ,P 〈0.05） ,and the onset time in observation group was shorter than that in control group [ （7.3±0.5 ） h vs （ 14.7 ± 2.1 ） h, P 〈 0.05 ]. The rate of complications in observation group was 8.0%, while 17.4% in control group, and the former was lower than the latter （P 〈 0.05 ）. Conclusion Methylprednisolone and aminophylline added to conventional expectant and supporting treatment for bronchial asthma could make the onset time shorter, the curative effect accurate and safety. It was worthy of clinical application.