原发性肝癌术后抗复发治疗

The effect and utilization of Comprehensive treatment on intrahepatic recurrence after hepatic resection for hepatocellular carcinoma

目的探讨原发性肝癌根治性切除术后联合肝动脉插管栓塞化疗（TACE）、抗乙型肝炎病毒及免疫治疗抗复发治疗对术后复发的影响。方法随访满2年的原发性肝癌根治性切除术患者60例，分为单纯手术组、术后综合治疗组各30例，对两组术后1年、2年肝内复发率进行回顾性分析。结果综合治疗组1年、2年肝内复发率分别为13％（4／30）、40％（12／30），显著低于单纯手术组的40％（12／30）和70％（21／30）（x2=4．176、4．310，均P〈0．05）。结论原发性肝癌根治性切除术后联合TACE、抗乙型肝炎病毒及免疫治疗的肝癌综合治疗方案可以延缓肝癌手术后复发。

Objective To explore the effect and utilization of comprehensive treatment on intrahepatic recur- rence after hepatic resection for bepatocellular carcinoma. Methods One and two year recurrent rate of 60 patients with hepatocellular carcinoma who underwent hepatic resection in a two-year follow up were analyzed retrospectively, control group 30 cases, comprehensive treatment group 30 cases. Results One and two year intrahepatic recurrent rate of comprehensive treatment is 13% （4/30） and 40% （12/30） respectively. The difference was statistically sing- nificant （x2 = 4. 176,4. 310, all P 〈 0.05）. Conclusion The effect of comprehensive treatment on postponing intra- hepatic recurrence after hepatic resection for hepatocellular carcinoma is obvious.