β-catenin与宫颈癌的相关性研究

Relationship of β-catenin and cervical cancer

目的探讨宫颈癌组织中β-catenin的表达及其与肿瘤侵袭转移的关系。方法采用免疫组化SP三步法检测70例宫颈癌组织及40例正常宫颈组织(对照组)中β-catenin蛋白的表达。结果宫颈癌组织中β-catenin的阳性表达率(73%)明显高于对照组,β-catenin与宫颈癌组织中的表达密切相关(P<0.01))。β-catenin异常表达与病理分化程度、临床分期、淋巴结转移有相关性(P<0.05)。结论β-catenin在宫颈癌组织中存在异常表达,其阳性表达与宫颈癌组织病理分化程度、临床分期、淋巴结转移有相关性。β-catenin有可能在宫颈癌组织的发生发展中发挥重要作用,其阳性表达与宫颈癌组织侵袭转移有密切关系,并可能成为判断宫颈癌组织转移及预后的指标之一。

Objective To explore the relationship of β-catenin and cervical cancer. Methods By immunohistochemical SP three-stage method, β-catenin expression of 70 cases of cervical cancer organizations and 40 patients with normal cervical tissue （control） were detected. Results The positive rate of beta catenin expression in cervical cancer tissues was higher than that of control group. Beta catenin express and cervical cancer tissue were closely related （P〈0. 01）. There was a correlation lymph node metastasis （P〈0.05）. Conclusion Beta catenin in cervical cancer abnormally expresses. There is a close relationship between invasion and metastasis, and may be judge organization transfer and prognosis of the cerical cancer indexes.