上皮性卵巢癌中癌胚抗原相关细胞黏附分子1和CD105的表达

Expression of carcinoembryonic antigen-related cell adhesion molecule 1 and CD105 in epithelial ovarian cancer

目的探讨上皮性卵巢癌中癌胚抗原相关细胞黏附分子1(CEACAM1)和血管内皮标志物CD105的表达及其与肿瘤血管生成的关系。方法应用免疫组织化学法检测62例上皮性卵巢癌组织及60例上皮性卵巢良性肿瘤组织中CEACAM1和CD105的表达,并记录微血管密度(MVD),对上皮性卵巢癌组织及良性肿瘤组织中CEACAM1、CD105的表达进行相关性分析。结果 CEACAM1和CD105在上皮性卵巢恶性肿瘤表达较高,而在卵巢良性肿瘤组织中表达较低。CEACAM1和CD105的表达与卵巢癌的病理分期呈显著正相关(r=0.847、0.776,P<0.01),随着上皮性卵巢癌恶性程度的升高,CEACAM1和CD105的表达均逐渐增高;CEACAM1的表达与CD105-MVD呈正相关(r=0.890,P<0.01)。结论 CEACAM1在卵巢组织中的表达增加可能与卵巢癌的发生和发展有关;CD105-MVD对评估上皮性卵巢癌恶性程度有重要意义;CEACAM1可能作为一种促血管生长因子而刺激肿瘤血管的生成。

Objective To investigate the relationship between the expression of carcinoembryonic antigen-related cell adhesion molecule 1 （CEACAM1） and CD105 ,and the relationship of them with tumor angiogenesis in epithelial ovarian canc- er. Methods The expressions of CEACAM1 and CD105 were detected by immunohistochemical method,and the microvessel density（MVD） was calculated. The correlation analysis of the expressions of CEACAM1 and CD105 was carried out in 62 specimens of epithelial ovarian cancer and 60 specimens of benign tumor tissue. Results The expressions of CEACAM1 and CD105 were higher in epithelial ovarian cancer than those in benign tumor tissue. The expressions of CEACAM1 and CD105 were positively related with pathology staging of ovarian cancer（ r = 0. 847,0. 776;P 〈 0.01 ） , with the increase of the degree of malignancy of epithelial ovarian cancer, CEACAM1 and CD105 expression gradually increased. The expression of CEACAM1 was positively related with CD105-MVD（r =0. 890 ,P 〈0.01 ）. Conclusion Overexpression of CEACAM1 may be related to the occurrence and development of ovarian cancer. CD105-MVD may be an important marker for evaluating the malignancy of epithelial ovarian cancer. CEACAM1 may stimulate tumor angiogenesis as a vascular growth factor.