摘要
目的:探讨VEGF和Ki-67在透明细胞肾细胞癌(ccRCC)中的表达及其相互关系。方法:采用免疫组化SP法检测64例ccRCC组织中VEGF和Ki-67的表达,同时选取15例正常肾组织作为正常对照。结果:CcRCC组织中VEGF、Ki-67阳性表达率分别为71.88%(46/64)、53.13%(34/64),而正常肾组织分别为26.67%(5/15)、13.33%(2/15),差异均有统计学意义。VEGF和Ki-67的阳性表达率与临床分期、Furhman分级及淋巴转移密切相关,而与患者性别、年龄无明显相关。VEGF与Ki-67的表达呈正相关。结论:VEGF和Ki-67与ccRCC的发生、发展及预后密切相关,两者检测对ccRCC术后治疗和预后有一定的指导意义。
Objective: To explore the expression and correlation between VEGF and Ki-67 in clear cell renal cell cancer(ccRCC).Methods: Surgical specimens in paraffin of 64 cases of renal clear cell carcinoma and 15 cases of normal renal tissue were collected.The protein expression of VEGF and Ki-67 were detected by immunohistochemical SP method.Results: The expression levels of VEGF and Ki-67 protein in ccRCC were significantly higher than those in normal renal tissue.The expression of VEGF and Ki-67 were closely correlated with clinical stages,Furhman grade and lymph node metastasis,but were not with age and gender.The expressions of VEGF and Ki-67 had a significant positive correlation.Conclusion: VEGF and Ki-67 may play an important roles in carcinogenesis of ccRCC.Combined detection of the expression of VEGF and Ki-67 is helpful to know the biological hehavior of ccRCC and to estimate the prognosis and the treatment of patients.
出处
《陕西医学杂志》
CAS
2012年第11期1447-1449,共3页
Shaanxi Medical Journal
基金
福建省卫生厅青年科研课题资助(NO.39135)
关键词
肾肿瘤
病理学
血管内皮生长因子
@Ki-67
免疫组织化学
腺癌
透明细胞
Kidney neoplasms/pathology Vascular endothe lial growth factors @GF Ki-67 Immunohistochemistry Adenocarcinoma
clear cell