透明细胞肾细胞癌中VEGF、Ki-67的表达及其相关性分析

Correlation between expression of VEGF and Ki-67 in clear cell renal cell cancer

目的:探讨VEGF和Ki-67在透明细胞肾细胞癌(ccRCC)中的表达及其相互关系。方法:采用免疫组化SP法检测64例ccRCC组织中VEGF和Ki-67的表达,同时选取15例正常肾组织作为正常对照。结果:CcRCC组织中VEGF、Ki-67阳性表达率分别为71.88%(46/64)、53.13%(34/64),而正常肾组织分别为26.67%(5/15)、13.33%(2/15),差异均有统计学意义。VEGF和Ki-67的阳性表达率与临床分期、Furhman分级及淋巴转移密切相关,而与患者性别、年龄无明显相关。VEGF与Ki-67的表达呈正相关。结论:VEGF和Ki-67与ccRCC的发生、发展及预后密切相关,两者检测对ccRCC术后治疗和预后有一定的指导意义。

Objective： To explore the expression and correlation between VEGF and Ki-67 in clear cell renal cell cancer（ccRCC）.Methods： Surgical specimens in paraffin of 64 cases of renal clear cell carcinoma and 15 cases of normal renal tissue were collected.The protein expression of VEGF and Ki-67 were detected by immunohistochemical SP method.Results： The expression levels of VEGF and Ki-67 protein in ccRCC were significantly higher than those in normal renal tissue.The expression of VEGF and Ki-67 were closely correlated with clinical stages,Furhman grade and lymph node metastasis,but were not with age and gender.The expressions of VEGF and Ki-67 had a significant positive correlation.Conclusion： VEGF and Ki-67 may play an important roles in carcinogenesis of ccRCC.Combined detection of the expression of VEGF and Ki-67 is helpful to know the biological hehavior of ccRCC and to estimate the prognosis and the treatment of patients.