阿托伐他汀对原发性高血压患者动态脉压的影响

Effect of atorvastatin on pulse pressure in patients with essential hypertension

目的:观察阿托伐他汀对原发性高血压患者动态脉压的影响。方法:将108例原发性高血压患者随机分为一般治疗组和阿托伐他汀治疗组各54例,其中一般治疗组患者仅给予常规控制血压治疗,阿托伐他汀治疗组在常规控制血压治疗的基础上给予阿托伐他汀40 mg/d口服,共观察12周。分别于治疗前和治疗4、8、12周监测2组患者24 h动态血压1次,计算平均动态脉压。结果:阿托伐他汀治疗组患者动态脉压水平在治疗前与一般治疗组差异无统计学意义(P>0.05),治疗后均明显低于一般治疗组(P<0.01),且随着治疗时间的延长阿托伐他汀治疗组患者动态脉压水平有明显降低趋势(P<0.01)。结论:阿托伐他汀具有改善原发性高血压患者动态脉压水平的作用。

Objective：To evaluate the effect of atorvastatin on pulse pressure in patients with essential hypertension（EH）. Methods：One hundred and eight EH patients were randomly allocated into two groups：common treated group（54 cases） and atorvastatin treated group（54 cases）.Patients in common treated group were accepted common treatment and those in atorvastatin treated group were treated with atorvastatin 40 mg daily besides common treatment.All of them were treated for 12 weeks.Pulse pressure was compared between the two groups before treatment and after 4,8,12 weeks treatment. Results：There was no difference of pulse pressure between two groups before treatment（P0.05）,but was significantly lower in atorvastatin treated group than in common treated group after treatment（P0.01）,and with the treatment prolonging,pulse pressure had an obvious lower tendency in atorvastatin treated group（P0.01）. Conclusions：Atorvastatin could decrease pulse pressure effectively in patients with EH.