妊娠合并甲状腺功能亢进症对新生儿的影响

Effect of maternal hyperthyroidism on newborn

[目的]探讨妊娠期间甲亢及其治疗对新生儿的影响。[方法]选取妊娠合并甲亢并分娩新生儿者55例进行回顾性分析,其中未控组16例,早控组(孕28周前甲亢已控制满意直至分娩者)23例,晚控组(孕早中期甲功未控制至正常,孕28周后达正常直至分娩者)16例。同时,随机选取同期正常妊娠55例为对照,分析比较甲亢控制情况与新生儿低体重及新生儿黄疸的关系。[结果]甲亢组的早产率高于对照组(P<0.05)。母亲甲亢未控组,其新生儿平均出生体重低于母亲甲亢早控、晚控组,为(2823.5±119.4)g vs(3691.3±93.8)g、(3409.4±80.0)g,P<0.05;母亲甲亢晚控组,其新生儿平均出生体重与早控组差异无显著性意义,P>0.05;母亲甲亢未控组及晚控组,其新生儿黄疸发生率高于早控组(53.8%,25.0%vs 13.0%,P<0.05)。[结论]妊娠合并甲亢及早发现,早期系统治疗,可以有效降低新生儿低体重的发生率,降低新生儿黄疸的发生率。

[ Objective] To evaluate the effect of maternal hyperthyroidism on newborn. [ Methods] The clinical data of 55 cases of pregnant women with hyperthyroidism in Jan 2002 - Sep 2011 from the First Affiliated Hospital of Dalian Medical University were analyzed retrospectively, and the same period 55 patients randomly selected normal pregnancy as control group. Analysis of the birth weight and bilirnbin value of newborn babies were down between the un - controlled and con- trolled group. [ Results ] The average birth weight of newborn in mothers ~ disease un, controlled group is lower than the mothers ~ disease controlled group （2823.5 ＋ 119.4） g vs （ 3691.3 ~ 93.8 ） g, （ 3409, 4 ~ 80.0） g, P 〈 0.05 ; The average birth weight of newborn whose mothers＂ disease controlled until the third trimester is similar with the groups whose mothers~ disease controlled before that, P 〉 0.05. The jaundice rate of the newborn whose mothers＂ disease un - controlled or con- trolled until the third trimester is higher than the early controlled group （53.8% ,25.0% vs 13.0%, P 〈 0.05 ）. [ Con- clusion ] The hyperthyroidism with pregnancy should be diagnosed and treated systematically as early as we can. So that the incidence of neonatal LBW and jaundice can be prevent effectively.