纤维蛋白原和载脂蛋白AⅠ在急性冠脉综合征中的作用

Effect of fibrinogen and Apolipoprotein AⅠin acute coronary syndrome

急性冠脉综合征(acute coronary syndrome,ACS)是临床常见的心血管急症,其发病率和死亡率都很高,它是由吸烟、高血压、代谢综合征、糖代谢异常、凝血机制异常及脂蛋白代谢障碍等多种相关危险因素相互作用而导致的一组疾病。许多临床基础实验显示,血浆纤维蛋白原(Fibrinogen,FIB)水平升高是冠心病的独立危险因素,而载脂蛋白AⅠ(Apolipoprotein AⅠ,ApoAⅠ)水平在调节动脉粥样硬化中也起到主要作用。本文从二者的定义、分类及病理基础等入手,旨在运用全面综合的方法从其化学分子结构,作用机制等各个方面阐述其在ACS发生、发展及预后中的重要作用。

Acute Coronary Syndrome is the common clinical cardiovascular emergency case.Its incidence and mortality rates are very high.This disease is caused by multiple risk interrelated factors consisting of smoking,high blood pressure,metabolic syndrome,abnormal glucose metabolism,abnormal blood coagulation mechanism and lipoprotein metabolism disorder.Many basic clinical experiments have shown,Fibrinogen level＇s rising is the independent risk factors for coronary heart disease,and Apolipoprotein AⅠlevel for regulating atherosclerosis also plays a major role.Based on the combination of definitions,classification and pathological basis of above two,using comprehensive methods in their chemical structure,mechanism and other aspects,this paper expounds the important role of ACS occurrence,development and prognosis,providing the basis for further Clinical research.