超敏C-反应蛋白在新生儿败血症中的早期诊断价值

Value of high sensitive C-reactive protein in early diagnosis of neonate septicemia

目的探讨超敏C-反应蛋白检测在新生儿败血症早期诊断中的应用价值。方法蚌埠市第二人民医院诊治的新生儿败血症患儿在采血进行病原菌培养时,对其进行血清超敏C-反应蛋白定量分析。选择54例新生儿血培养结果阳性患儿做为治疗前组,新生儿败血症患儿复查血培养时,再次测定血清超敏C-反应蛋白,血培养转为阴性时做为治疗后组,另选取无感染征象新生儿42例为对照组。观察比较各组患儿血清超敏C-反应蛋白的变化。结果新生儿败血症患儿超敏C-反应蛋白阳性率治疗前为90.7%(49/54),治疗后为25.9%(14/54),对照组为14.3%(6/42)。各组超敏C-反应蛋白间比较差异有统计学意义(P<0.05)。结论血清超敏C-反应蛋白测定有助于新生儿败血症的临床早期诊断。

Objective To investigate the application value of high sensitive C-reactive protein in early diagnosis of neonate septicemia. Methods The specimen from neonate were collected, pathogen cultivation was conducted and quantitative analysis of high sensitive C-reactive protein was performed. Fifty-four cases of neonate with positive blood culture were set as pre-treatment group, the neonates with negative blood culture by reexamination were set as post-treatment group, and the neonates with no sign of infection were set as control group. The levels of high sensitive C-reactive protein of the three groups were compared. Results The positive rates of high sensitive C-reactive protein in pre-treatment group, post-treatment group and control group were 90.7% （49/ 54）, 25.9% （14/54） and 14.3% （ 6/42 ）, respectively. The differences among the three groups were significant （ P 〈 0. 05 ）. Conclusion The deetection of high sensitive C-reactive protein is helpful for the early diagnosis of neonate septicemia.