RFA联合TACE治疗中晚期肝癌的疗效观察

THE FIRST AFFILIATED HOSPITAL OF BENGBU MEDICAL COLLEGE DEPARTMENT OF HEPATOBILIARY SURGERY

目的观察射频消融术(RFA)联合导管动脉栓塞化疗(TACE)治疗晚期肝癌的临床效果。方法回顾性分析2005年6月～2011年6月蚌埠医学院第一附属医院肝胆外科92例接受TACE及RFA治疗的中晚期原发性肝癌患者,其中88例具有完整的临床治疗过程及随访资料,共43例接受TACE治疗(TACE组),45例接受TACE联合RFA治疗(TACE.RFA组),两组患者的一般临床资料及肿瘤情况差异无统计学意义,比较其生存状况并予以分层分析。结果手术前后螺旋CT摄片或彩超比较显示消融效果良好,两组治疗后肿瘤坏死总有效率(CR+PR)分别为67.4%(29/43)、91.1%(41/45),两组间差异有统计学意义(P<0.05)。接受RFA的患者与对照组相比其生存质量及生存时间均有显著提高。结论对于难以手术切除的原发性肝癌患者,RAF联合TACE的治疗效果明显优于单纯TACE。

Objective To observe the effect of radiofrequency catheter ablation （RFA） combined with transcatheter arterial chemoembolization （TACE） for advanced hepatocellular carcinoma clinical effect. Methods a retrospective analysis of 2005 June to 2011 June, the First Affiliated Hospital of Bengbu Medical College Department of hepatobiliary surgery 92 cases underwent TACE and RFA treatment in advanced primary liver cancer patients, including 88 cases with complete clinical treatment and follow - up data, a total of 43 patients treated with TACE （TACE group） ,45patients received TACE combined with RFA treatment （group TACE. RFA）, two groups of patients with clinical data and tumor of the differences were not statistically significant, comparing their survival status and be stratified analysis. Results before and after the operation of spiral CT radiography or color comparison shows ablation effect is good, the two groups after the treatment of tumor necrosis rate （CR ＋ PR） were 67.4% （29/43 ） ,91.1% （41/45 ）, the difference between the two groups was statistically significant （ P 〈 0. 05）. Patients undergoing RFA compared with the control group, the quality of life and survival time were significantly improved. Conclusions about the difficulty of operation resection of primary liver cancer pa- tients, RAF combined TACE treatment effect was better than that of pure TACE.