原发性干燥综合征肺部．CT表现及临床意义

The lung CT findings in patients with primary Sj^gren＇s syndrome and clinical significance

目的探讨原发性干燥综合征（pSS）患者肺部CT表现及临床意义。方法回顾性分析68例pSS患者肺部CT图像，观察各种病变的分布特征。用CT视觉评分方法定量分析肺内病变，并用二分类非条件Logistic回归分析探讨与pSS患者肺动脉高压（PAH）、抗SSB抗体阳性的关系。结果68例pSS患者PAH13例（19％），抗SSB抗体阳性25例（37％），肺部CT表现正常13例（19％），小叶间隔增厚、磨玻璃影、小叶内间质增厚在本组病例中出现的频率较高（〉40％）。肺内病变分布具有周围分布、下肺分布为主的特点。小叶间隔增厚、囊性变与pSS患者PAH相关（OR=1．780、2．5i3，P〈0．05），囊性变与患者抗SSB抗体阳性有明显相关性（OR=10．530，P〈O．05）。结论肺部CT可以定量分析DSs肺损害的程度，并能为临床治疗及预后提供帮助。

Objective To investigate the lung CT findings in patients with primary SjOgren＇s syndrome （pSS） and clinical significance. Methods Images of lung CT scans of 68 patients with pSS were retrospectively observed. The distribution characteristics of lung lesions were observed. CT visual score were used to quantitatively analyze lung lesions. Binary classification unconditional logistic regression analysis was used to investigate the relationship between pulmonary arterial hypertension （PAH） and anti-SSB seropositivity in Patients with pSS. Results The 68 cases of patients with pSS, PAH in 13（ 19% ）, anti-SSB seropositivity in 25 （37%）, CT shows normal in 13 （ 19% ）, intedobular septal thickening, ground-glass opacity and intralobular interstitial thickening were frequent findings. The lesion distribution was in the peripheral and lower lung fields. Interlobular septal thickening and cysts were associated with PAH in Patients with pSS （OR=1.780, 2.513, P〈O.05）, cysts was significantly associated with anti-SSB seropositivity （OR =10.530, P〈O.05）. Conclusion Lung CT can quantitatively analyze the degree of pSS lung damage, and provide helps for clinical treatment and prognosis.