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Thl7细胞与系统性红斑狼疮研究进展 被引量：3

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摘要 2005年首次定义辅助l性T细胞17（Th17细胞）是一种完全不同于Th1和Th2的CD4＋T细胞^[1]，并证实Th17细胞及其分泌的细胞因子白细胞介素（interleukin，IL）-17与多种自身免疫病的发病机制有关。
作者 鲁琳 王丹丹 李霞 孙凌云
机构地区 南京医科大学附属鼓楼医院风湿免疫科
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2012年第11期770-772,共3页 Chinese Journal of Rheumatology
基金 国家自然科学基金（30972736） 江苏省自然科学基金（BK2009035）
关键词 CD4+T细胞 系统性红斑狼疮 Th17细胞 细胞因子白细胞介素 系统性硬化症 自身免疫病 发病机制 TH2
分类号 R593.241 [医药卫生—内科学]
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  • 2Ikehara S, Inaba M, Yasumizu R, et al. Autoimmune diseases as stem cell disorders. Tohoku .1 Exr Med, 1994, 173: 141-155.
  • 3Sun LY, Akiyama K; Zhang HY, et al. Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans. Stem Ceils, 2009, 27: 1421- 1432.
  • 4Liang J, Zhang HY, Hua BZ, et al. Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study. Ann Rheum Dis, 2010, 69: 1423-1429.
  • 5Sun LY, Wang DD, Liang J, et al. Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus. Arthritis Rheum, 2010, 62: 2467-2475.
  • 6Gu Z, Akiyama K, Ma X, et al. Transplantation of umbilical cord mesenchymal stem cells alleviates lupus nephritis in MRL/lpr mice, Lupus, 2010, 19: 1502-1504.
  • 7Smith EL, Shmerling RH. The American College of Rheumatolo- gy criteria for the classification of systemic lupus erythematosus: strengths, weaknesses, and opportunities for improvement. Lu- pus, 1999, 8: 586-595.
  • 8Von Delwig A, Locke J, Robinson JH, et al. Response of Thl7 cells to a citrullinated arthritogenic aggrecan peptide in patients with rheumatoid arthritis. Arthritis Rheum, 2010, 62: 143-149.
  • 9Fitzgerald DC, Cirie B, Touil T, et al. Suppressive effect of IL- 27 on encephalitogenie Thl7 cells and the effector phase of ex- perimental autoimmune encephalomyelitis. J Immunol, 2007, 179: 3268-3275.
  • 10Nauta AJ, Fibbe WE. Immunomodulatory properties of mes- enchymal stromal cells. Blood, 2007, 110: 3499-506.

共引文献43

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中华风湿病学杂志
2012年 第11期

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