C反应蛋白在不稳定型心绞痛及急性心肌梗塞预后预测中的价值

Prognostic Value of C-Reactive Protein in Patients with Unstable Angina Pectoris and Acute Myocardial Infarction

【目的】评价C反应蛋白 (CRP)预测不稳定型心绞痛和急性心肌梗塞患者预后的价值。【方法】测定 40例冠状动脉造影正常者、46例不稳定型心绞痛和 32例急性心肌梗塞患者血清CRP含量。【结果】不稳定型心绞痛和急性心肌梗塞患者血清CRP含量较冠状动脉造影正常组升高 (分别为P <0 0 1,P <0 0 0 1) ,急性心肌梗塞组CRP升高最显著。在不稳定型心绞痛和急性心肌梗塞组 ,主要心脏事件发生 (心绞痛组发生急性心肌梗塞、心衰、泵衰、梗塞后心包炎 )多数病例 ,在同组中处于CRP含量较高水平。不稳定型心绞痛组CRP与左室射血分数无关 ,与急性心肌梗塞组成负相关 (r=- 0 72 ,P <0 0 0 1)。【结论】在不稳定型心绞痛和急性心肌梗塞 ,血清CRP增高是预后不良的一个预测因子。

Objective This study assessed the prognostic value of C reactive protein (CRP) in unstable angina and acute myocardial infarction (AMI). Methods 40 patients with angiograghically proven normal coronary artery, 46 patients with unstable angina and 32 patients with AMI were prospectively studied, serum concentrations of CRP were measured. Results Concentrations of CRP were higher in patients with unstable angina and AMI than those in normal group. CRP was highest in patients with AMI. The rate of major adverse cardiac events (AMI in unstable angina group, heart failure, pump failure and postinfarctive pericarditis) were more higher in both unstable angina and AMI patients with increased CRP. CRP was negatively correlated with left ventricular ejection fraction (r=-0.72,P<0 001) in patients with AMI. Conclusion In patients with unstable angina and AMI, increased CRP is a predictor of worse prognosis.