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DAG-PKC信号传导通路与糖尿病血管并发症 被引量：5

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摘要 高血糖可引起多种组织细胞内二脂酰甘油 (DAG)水平升高 ,DAG可激活蛋白激酶C(PKC)。最近研究表明 ,持续高血糖引起的DAG PKC系统激活与糖尿病多种血管异常关系密切。PKC是由一个多基因家族编码的多肽类物质 ,至少有 1 1种亚型。在多个PKC亚型中 ,β、γ亚型在糖尿病动物的血管系统中优先被激活。选择性PKC β抑制剂 (LY333531 )能逆转或减轻啮齿类糖尿病动物的血管异常 。
作者 左祥生 罗敏
机构地区 上海第二医科大学附属瑞金医院
出处 《国外医学（内分泌学分册）》 2000年第3期126-128,共3页 Foreign Medical Sciences(Section of Endocrinology)
关键词 DAG PKC 糖尿病性血管病 PKC-β抑制剂 信号传导
分类号 R587.202 [医药卫生—内分泌]
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参考文献16

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同被引文献40

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引证文献5

二级引证文献14

国外医学（内分泌学分册）
2000年 第3期

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