Matriptase在人类肿瘤中的作用

Matriptase and Human Tumors

Ⅱ型跨膜丝氨酸蛋白酶Matriptase与多种实体肿瘤(如乳腺癌、前列腺癌、妇科肿瘤及头颈部鳞状细胞癌等)的发生、发展密切相关。Matriptase通过激活肝细胞生长因子前体、尿激酶前体、蛋白酶激活受体2等启动一系列蛋白酶级联反应,影响肿瘤细胞的生长和黏附,促进肿瘤细胞的侵袭和迁移。此外,Matriptase与其同源性抑制剂肝细胞生长因子激活物抑制剂1比例失调后,也可导致肿瘤的发生。Matriptase在肿瘤发生、发展中的重要作用,使其有望成为肿瘤诊断的一个新指标,抑制Matriptase蛋白酶活性可能成为肿瘤治疗的新策略。

Matriptase,a member of the type Ⅱ transmembrane serine protease family,is involved in epithelium-derived solid tumors,such as breast cancer,prostate cancer,gynecology tumors,head and neck squamous cell carcinoma.Matriptase initiates a series of protease cascades via activation of PAR-2,pro-HGF,pro-UPA and other signaling molecules,which may promote tumor cell growth and adhesion,thereby enhancing tumor invasion and migration.The imbalance activities of Matriptase and its cognate inhibitor HAI-1 may result in a variety of tumors.Given its important role in tumor development,Matriptase might represent a novel diagnostic marker as well as a new therapeutic target for human tumors.