摘要
MicroRNA(miRNA)是一种非编码小分子RNA,在转录后水平调节基因表达,从而调节细胞生长、增殖、分化、凋亡等多种生命过程。膀胱癌是泌尿系统最常见的肿瘤。研究发现膀胱癌中部分miRNA表达异常,与膀胱癌的发生密切相关。部分差异表达的miRNA作为生物标志物用以膀胱癌的诊断、分级分期、治疗等。这些研究为膀胱癌的诊断和治疗提供了新的方向。
MicroRNA（miRNA）are small,noncoding RNAs that regulate gene expression post-transcriptionally,thereby regulate many kinds of life processes such as cell growth,proliferation,differentiation and apoptosis.Bladder cancer is the most common urinary tumor.It is reported that some miRNAs are abnormally expressed in bladder cancer,which may be related to the genesis of bladder cancer.Several differentially expressed miRNAs may be used for diagnosis,pathological classification and treatment for bladder cancer as biological markers,which will provide a new direction for the diagnosis and treatment.
出处
《医学综述》
2012年第21期3535-3537,共3页
Medical Recapitulate
基金
国家自然科学基金面上项目(30973385)
