EpCAM与肿瘤关系的研究进展

Research Progress of Correlations between EpCAM and Neoplasms

上皮细胞黏附分子(EpCAM)具有加快细胞周期、促进细胞增殖、分化、迁移以及免疫逃逸等多种生物学功能。基于EpCAM特异性单抗的新技术和新药物能够高效、准确并特异地杀灭肿瘤细胞。最近研究表明,EpCAM可作为肿瘤干细胞研究的筛选标志,与其他共标志细胞具有自我更新、强致瘤性及遗传稳定性等特性。因此,EpCAM作为一种新型肿瘤标志物,不仅用于肿瘤的早期诊断、治疗及预后判断,而且可用于肿瘤干细胞理论研究,为肿瘤干细胞分子生物学的研究奠定基础。

Epithelial cellular adhesion molecule（EpCAM）possesses the biological functions of accelerating cell cycle,promoting cell proliferation,differentiation,migration and immune escape.The research and exploitation of latest technology and drug,on account of EpCAM specificity monoclonal antibody,can kill tumor cells highly effectively,precisly,and specifically.Recency research indicates,EpCAM,as a screening marker of tumor stem cell,as well as other co-markers,possesses the characteristics self-renewal,high oncogenicity and hereditary stability.Accordingly,as a new type of tumor marker,EpCAM is not only utilized in tumor early diagnosis,treatment and prognosis judgment,but also in theoretical study of tumor stem cell,establishing the foundation of molecular biology research of tumor stem cell.