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骨髓间充质干细胞对1型糖尿病的治疗作用

Application of Bone Marrow Mesenchymal Stem Cells in Treating Type 1 Diabetes Mellitus
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摘要 骨髓间充质干细胞(BMSCs)具有不断自我更新的特性和多向分化的潜能,在体外可被诱导分化为胰岛样细胞,并发挥类似β细胞的作用。另外,BMSCs所特有的低免疫原性及其免疫调节作用可能通过抑制免疫细胞参与的β细胞的自身免疫攻击,从病因上根治1型糖尿病,为临床1型糖尿病的治疗提供一条新思路。 Due to the constant self-renewal capacity and high potential of multilineage differentiation,bone marrow mesenchymal stem cells（BMSCs）can be induced to form pancreatic islet-like cells in vitro,which can play the same role as pancreatic islet cells.Besides,their peculiar low immunogenicity and immunomodulation may restrain the auto-immune attacking to beta cells,and cure the type 1 diabetes from the etiology,which might lead to a new cell replacement therapy for type 1 diabetes in clinical.
作者 彭红 陈秋
机构地区 泸州医学院附属医院内分泌科
出处 《医学综述》 2012年第21期3641-3643,共3页 Medical Recapitulate
关键词 糖尿病 骨髓间充质干细胞 机制 Diabetes mellitus Bone marrow mesenchymal stem cells Mechanism
分类号 R587.1 [医药卫生—内分泌]
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参考文献21

  • 1Abdel Aziz MT, EI-Asmar MF, Haidara M, et al. Effect of bone marrow-derived mesenchymal stem cells on cardiovascular compli- cations in diabetic rats[ J]. Med Sci Monit ,2008,14 (11 ) : BR249- BR255.
  • 2Chen LB ,Jiang XB, Yang L. Differentiation of rat marrow mensen- chymal stem cells into pancreatic islet-cell [ J ]. World J Gastroen- terol, 2004,10 ( 20 ) : 3016 -3020.
  • 3Li L, Li F, Qi H, et al. Coexpression of Pdx-1 and betacellulin inmesenchymal stem cells could promote the differentiation of nestin- positive epithelium-like progenitors and pancreatic islet-like sphe- roids[ J]. Stem Cells Dev,2008,17(4) :815-823.
  • 4Aggarwal S, Pittenger MF. Human mesenchymal stem cells modu- late allogeneic immune cellresponses [ J ]. Blood, 2005,105 ( 4 ) : 1815-1822.
  • 5Tritt M, Sgouroudis E, D' Hennezel E, et al. Functional wanning of naturally occuring CD4 + regulatory T-cells contributes to the onset of autoimmune diabetes [ J ]. Diabetes,2008,57 ( 1 ) : 113-123.
  • 6Madec AM, Mallone R, A fonso G, et al. Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells [J]. Diabetologia,2009,52(7) :1391-1399.
  • 7Krampera M, Glennie S, Dyson J, et al. Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specif- ic T cells to their cognate peptide [ J ]. Blood,2003,101 (9) :3722- 3729.
  • 8Rasmusson I, Ringden O, Sundberg B, et al. Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not acti- vated cytotoxic T lymphocytes or natural killer cells [ J ]. Transplan- tation, 2003,76 ( 8 ) : 1208-1213.
  • 9Krampera M, Cosmi R, Angeli R, et al. Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesen- chymal stem cells[ J]. Stem Cells,2006,24(2) :386-398.
  • 10Corcione A, Benvenuto F, Ferretti E, et al. Human mesenchymal stem cells modulate B-cell functions [ J ]. Blood, 2006,10 ( 1 ) : 367 - 372.

二级参考文献15

  • 1Garcia R, Aguiar J, Alberti E, etal. Bone marrow stromal cells pruduce nerve growth factor and glial cell line-derived neurotrophic factors[J]. Biochem Biophys Res Cornmun, 2004, 316(3): 753-754.
  • 2Maehado AF, Zimmerman EF, Hovland DN Jr, et al. Diabetic embryo-pathy in C57BL/6J mice. Altered fetal sex ratio and impact of the splotch allele [J].Diabetes, 2001, 50 (5): 1193-1199.
  • 3Lu Y, Jin X, Chen Y, et al. Mesenchymal stem cells protect islets from hypoxia/reoxygenation induced injury [J]. Cell Biochem Funct, 2010, 28(8): 637-643.
  • 4Roh D, Nelson GN, Udelsman BV, et al. Centrifugal seeding increases seeding efficiency and cellular distribution of bone marrow stromal cells in porous biodegradable scaffolds[J]. Tissue Eng, 2007, 13(11) : 2743-2749.
  • 5Nauta AJ, Westerhuis G, Kruisselbrink AB, et al. Donorderived mesenehyrnal stem cells are immunogenic in an allogeneie host and stimulate donor graft rejection in a nonmyeloablative setting[J]. Blood, 2006, 108(6): 2114-2120.
  • 6Shapiro AM, Ricordi C, Hering BJ, et al. International trial of the edmonton protocol for islet transplantation[J]. N Engl J Med, 2006, 355(13): 1318-1330.
  • 7Nanii SA, Shapiro AM. Advances in pancreatic islet transplantation in humans[J]. Diabetes Obes Meta, 2006,8(1): 15-25.
  • 8Ryan EA, Paty BW, Senior PA, etal. Five-yearfollow-up after clinical islet transplantation [J].Diabetes, 2005, 54 (7): 2060-2069.
  • 9Frank A, Deng S, Huang X, et al. Transplantation for type- 1 diabetes comparison of vascularized whole-organ pancreas with isolated pancreatic islets[J]. Ann Surg, 2004, 240 (4): 631-643.
  • 10Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glueocorticoid-free immuno-suppressive regimen[J]. N Engl J Med, 2000, 343(3): 230-238.

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医学综述
2012年 第21期

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