对苯二甲酸亚慢性肾毒效应的动态观察

Changes in the Subchronic Nephrotoxicity Induced by Terephthalic Acid

为研究对苯二甲酸 (TPA )亚慢性毒性并为制定其卫生标准提供依据 ,以 5 0 0 0、5 0 0、5 0mg/kg 3个剂量TPA对SD大鼠连续染毒 90天 ,动态观察大鼠血清酶 (AST、GPT、ALB、ALP、NAG、GGT)和尿酶 (AST、ALP、NAG、GGT、α1—MG )等参数的变化。结果表明 :3 0天时 ,5 0 0 0mg/kg剂量组尿α1-MG、NAG有一过性升高 (P <0 0 5 ) ,5 0 0、5 0mg/kg剂量组ALP活性在第 3 0天、60天和 90天时明显高于对照组 (P <0 0 5 ) ;3个剂量组AST活性呈下降趋势。提示在本次试验条件下 ,TPA无明显肝脏毒性、但有轻度的肾脏毒性。

In order to study the subchronic toxicity of terephthalic acid and to provide basis for its health standard,SD rats were administrated therephthalic acid by oral forage at doses of 5000,500 and 50mg/kg body weight/day for 90 days consecutively.Control animals received normal feed.The biochemical parameters including ALB,AST,GTP,GGP,ALP and NAG in serum and AST,ALP,GGT,NAO,α\-1-MG in urine were observed dynamically.The results showed that urinary α\-1-MG level and NAG activity increased significantly(P<0 .05) on day 30 at 5000mg/kg group,and that ALP activity got higher(P<0.05) on day 30,60 and 90 at 5000mg/kg and 500mg/kg groups,as compared with the controls.But AST showed decreasing trend at the three dosage groups. There were no obvious changes in serum parameters. These results suggest that terephthalic acid may be with a mild toxicity to kidney but without any injury to liver.