知柏地黄丸对甲状腺功能亢进症患者抗氧化指标的影响

Effect of Zhibai-dihuang Pill on Serum Antioxidation Indices in Patients with Hyperthyroidism

目的探讨知柏地黄丸治疗甲状腺功能亢进(简称甲亢)的疗效以及对血清抗氧化指标的影响。方法 120例确诊为甲亢的患者随机分为试验组和对照组,每组各60例,试验组采用知柏地黄丸联合丙硫氧嘧啶治疗,对照组仅采用丙硫氧嘧啶治疗。观察治疗前后患者心率、体质量变化、血清的总三碘甲状腺原氨酸(T3)、四碘甲状腺原氨酸(T4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)的水平以及血清超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GPX)的活性及丙二醛的含量。结果与治疗前相比,试验组和对照组治疗后的心率和血清MDA浓度降低、体质量增加,血清甲状腺素指标上升,血清SOD和GPX的活性增高,并且组间比较,差异均具有统计学意义(P<0.01)。结论知柏地黄丸联合丙硫氧嘧啶治疗甲亢能够更好地改善患者的临床症状、血清甲状腺素的水平以及血清抗氧化指标的活性。

Objective To investigate the effect of Zhibai-dihuang pill on the patients of hyperthyroidism and the antioxidation indices of the serum.Methods 120 hyperthyroidism patients were divided randomly into the trial group and control group,60 patients in each group.The trial group was treated with Zhibai-dihuang pill combined with propylthiouracil,while the control group was treated with propylthiouracil.The heart rate,body weight,three triiodothyronine（T3）,four triiodothyronine（T4）,free three triiodothyronine（FT3）,free four triiodothyronine（FT4）,thyroid stimulating hormone（TSH）and the serum level of superoxide dismutase（SOD）,glutathione peroxidase（GPX）and malondialdehyde（MDA）of patients in both groups were measured.Results Compared with before treatment,the heart rate and serum MDA concentration decreased,body weight and serum SOD,GPX activity increased,thyroid hormone indexes improved in both groups after treatment,and there were significantly difference between the trial group and the control group（P0.01）.Conclusion Zhibai-dihuang pill combined with propylthiouracil can improve the hyperthyroidism patient′s clinical symptoms,serum thyroid hormone levels and serum antioxidant activity indexes.