联合巴曲酶治疗急性脑桥旁正中梗死疗效观察

Observation on the efficacy of Batroxobin in the treatment of patients with acute paramedian pontine infarction

目的评价联合巴曲酶(东菱迪芙)治疗急性脑桥旁正中梗死的临床效果。方法急性脑桥旁正中梗死患者78例,采用随机对照方法分为治疗组和对照组。2组均采用阿司匹林0.1g qd口服,低密度脂蛋白胆固醇>2.06mmol/L辛伐他汀20mg每晚口服,0.9%氯化钠250mL注射液加血塞通注射液400mg静滴作为基础治疗。治疗组加巴曲酶注射液静滴,即巴曲酶加入生理盐水100mL静滴,首次10BU,隔日1次,以后5BU/次,共用3次,对照组加用安慰剂静滴。比较2组进展性卒中的发生率。结果疗程结束进展性卒中的发生率治疗组(21.6%)较对照组(41.5%)显著降低(P<0.01)。结论巴曲酶治疗急性脑桥旁正中梗死能显著降低进展性卒中的发生率。

Objective To evaluate the efficacy of Batroxobin in the treatment of patients with acute paramedian pontine infarction.Methods Seventy-eight patients with acute paramedian pontine infarctions were randomly divided into the control group（n=41） and study group（n=37）.Patients in both groups received aspirin enteric-coated tablets（0.1 g daily） and Xuesaitong injection（400 mg added into 250 mL normal saline once a day）.Simvastatin was additionally administered if the level of low density lipoprotein over 2.06 mmol/L.The study group was then intravenously given with Batroxobin 10 BU,5 BU and 5 BU every other day.The same dose placebo was intravenously administered in the control group.NIHSS was used to compare the incidence of stroke in progression in the two groups.Results The incidence of stroke in progression in the study group（21.6%） was significantly lower than the control group（41.5%,P0.01）.Conclusion We proposed that Batroxobin in the treatment of patients with acute paramedian pontine infarction could significantly reduce the incidence of stroke in progression.