摘要
目的评价事件相关电位(ERP)对帕金森病伴抑郁症患者的诊断价值。方法应用听觉经典Oddball序列和视觉非经典Oddball序列分别对正常健康人、帕金森病不伴抑郁症患者、帕金森病伴抑郁症患者进行ERP检查,记录其电生理指标。结果听觉模式下诱发的P300潜伏期和波幅,3组间无明显差异;视觉模式下诱发的P450,帕金森病伴抑郁症组潜伏期较其他2组明显延长,波幅较其他2组明显降低;帕金森病伴抑郁症组患者潜伏期与汉密尔顿得分呈正相关(r=0.382,P<0.05),波幅与得分呈负相关(r=-0.412,P<0.05)。结论一定模式下的ERP对帕金森病伴抑郁症患者的诊断提供了较为可靠的电生理指标。
Objective To evaluate the diagnosis value of event-related potential (ERP) on the depression patients with Parkinson's disease. Methods Normal subjects, no-depression patients and the depression patients with Parkinson's disease were evaluated with ERP, which evoked by classical auditory Oddball model and non-classical visual Oddball paradigm, and the electrophysiological signs were recorded. Results The latency and amplitude of P300 wave evoked by auditory paradigm were no obvious differenee within three groups; the latency of P450 wave evoked by visual paradigm was significantly prolonged and the amplitude of P450 wave was lower in patients with depression; there was a positive correlation between the: latency of P450 and HHMD score(r=0. 382,P〈0.05 ), there was a negative correlation between the amplitude and HHM,D score(r=- 0. 412,P〈0.05). Conclusion ERP evoked by established paradigm is a relatively reliable method to detect the depression in Parkinson'~s disease patients.
出处
《中国实用神经疾病杂志》
2012年第20期13-15,共3页
Chinese Journal of Practical Nervous Diseases