香血藤中倍半萜类化学成分研究

Sesquiterpenes from stem of Schisandra glaucescens

目的:研究香血藤Schisandra glaucescens的化学成分。方法:以硅胶柱、凝胶柱色谱分离,制备HPLC纯化,采用MS,NMR等波谱方法进行结构鉴定。结果:从石油醚部位分离得到12个化合物:t-杜松醇(t-cadinol,1),α-杜松醇(α-cadinol,2),榧树醇(torreyol,3),(+)-ent-epicubenol(4),ent-T-muurolol(5),(-)-15-hydroxycalamenene(6),(-)-cubebol(7),4-epi-cubebol(8),石竹烯醇-I(caryophyllenol-I,9),石竹烯醇-II(caryophyllenol-II,10),oxyphyllenodiols A(11),caryolane-1,9β-diol(12)。结论:化合物4,6～12均首次从该属植物中分得,化合物1～12均首次从该植物中分得。

Objective： To study the chemical constituents from Schisandra glaucescens. Method： The chemical constituents were separated and purifed with silica gel, gel column chromatography preparative H_PLC, and their structures were identified by such spectra/ methods as MS and NMR. Result ： Twelve compounds were separated from petroleum ether fractions, and identified as t-cadinol （ 1 ）, α-cadi- nol （2）, torreyol （3）, （ ＋ ）-ent-epicubenol （4）, ent-T-muurolol （5）, （ - ）-15-hydroxycalamenene （6）, （ - ）-cubebol （7）, 4-epi-cube- bol （8）, caryophyllenol-I （9）, caryophyllenol-II （10）, oxyphyllenodiols A （11）, caryolane-1,9β-diol （12）. Conclusion： Compounds 4, 6- 12 were separated from the genus for the first time, while compounds 1-12 were separated from this olant for the first time.