期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

在线红外法在N-羟基琥珀酰亚胺酯合成中的应用 被引量：2

In-situ monitoring of N-hydroxysuccinimide esters using FTIR/ATR spectroscop
下载PDF
导出
摘要 在线红外法是一种通过监测反应体系中各组分浓度变化,直观体现反应历程的监测方法。具有无需取样,灵敏度高,时效性强,应用范围广泛等优点。在N-羟基琥珀酰亚胺酯的合成中采用在线傅里叶红外法,通过实时直观的反应进程,成功克服了实验中的困难,并且有利于进一步的条件优化。所得一系列产物的结构均经过1HNMR确证。 In situ Fourier transform infrared is a method that reflects real-time reaction process by monitoring the concen- tration of every component. It has the advantages of non-man- ual sampling,high sensitivity and wide application range. We have adopted in situ Fourier transform infrared（FTIR） in the synthesis of N-hyroxysuccinimide esters. Not only did we get the desired results, but also accumulate important data for the subsequent optimization of reaction conditions. The structure was confirmed by 1 HNMR.
作者 李启麟 冯文化
机构地区 中国医学科学院北京协和医科大学药物研究所
出处 《化学试剂》 CAS CSCD 北大核心 2012年第11期1038-1040,共3页 Chemical Reagents
基金 国家"十一五"重大专项关键技术--创新高效合成项目(2009ZX09501-006) 国家"十一五"重大专项化药合成平台资助项目(2009ZX09301-003-1-1)
关键词 活性酯 在线红外 N-羟基琥珀酰亚胺酯 active ester react IR N-hydroxysuccinimide
分类号 O623 [理学—有机化学]
  • 相关文献

参考文献7

  • 1PAGENKOPF B L, KRUGER J, STOJANOVIC A, et al. Mechanistic insights into Cu-catalyzed asymmetric aldol reactions:chemical and spectroscopic evidence for a metalloenolate intermediate [ J ]. Angew. Chem. Int. Ed. , 1998,37(22) :3 124-3 126.
  • 2KONSLER R,KARL J,JACOBSEN E. Cooperative asymmetric catalysis with dimeric salen complexes[J]. J. Am. Chem. Soc. ,1998,120(41) :10 780-10 781.
  • 3PINTAR A, MALACEA R, PINEL C, et al. In-situ monitoring of catalytic three-phase enantioselective hydrogena- tion using FTIR/ATR spectroscopy [ J ]. Appl. Catal. A, 2004,264 ( 1 ) : 1-12.
  • 4陈玉岩,刘刚.万古霉素衍生物的合成与活性研究进展[J].药学学报,2007,42(5):463-469. 被引量：5
  • 5ANDERSON G W,ZIMMERMAN J E,CALLAHAN F M, et al. The use of esters of N-hydroxysuccinimide in pep- tide synthesis [ J ]. J. Am. Chem. Soc., 1964,86 (9) : 1 839-1 842.
  • 6LEBLOND C, WANG J, LARSON R, et al. A combined approach to characterization of catalytic reactions using in-situ kinetic probes[ J]. Top. Catal. , 1998,5 : 149-158.
  • 7GAB J, MELZER M, KEHE K,et al. Quantification of hydrolysis of toxic organophosphates and organophospho- nates by diisopropyl fluorophosphatase from loligo vulgaris by in situ Fourier transform infrared spectroscopy [ J ]. Anal. Biochem. ,2009,385 ( 2 ) : 187-193.

二级参考文献25

  • 1Kerns R,Dong SD,Kahne D.The role of hydrophobic substituents in the biological activity of glycopeptides antibiotics[J].J Am Chem Soc,2000,122:12608-12609.
  • 2Eggert US,Ruiz N,Kahne D,et al.Genetic basis for activity differences between vancomycin and glycolipid derivatives of vancomycin[J].Science,2001,294:361-364.
  • 3Bleicher K,Lin M,Shapiro MJ,et al.Diffusion edited NMR:screening compound mixtures by affinity NMR to detect binding ligands to vancomycin[J].J Org Chem,1998,63:8486-8490.
  • 4Jeffrey M,Steven LC,Boger DL,et al.Synthesis and evaluation of vancomycin and vancomycin aglycon analogues that bear modifications in the residue 3 asparagine[J].Bioorg Med Chem Lett,2002,12:1319-1322.
  • 5Kerns R,Dong SD,Kahne D.The role of hydrophobic substituents in the biological activity of glycopeptide antibiotics[J].J Am Chem Soc,2000,122:12608-12609.
  • 6Fu X,Albermann C,Thorson JS,et al.Diversifying vancomycin via chemoenzymatic strategies[J].Org Lett,2005,7:1513-1515.
  • 7Neu HC.The crisis in antibiotic resistance[J].Science,1992,257:1064-1073.
  • 8Walsh CT.Molecular mechanisms that confer antibacterial drug resistance[J].Nature,2000,406:775-781.
  • 9Williams DH,Kalman JR.Structure and mode of action studies on the antibiotic vancomycin.Evidence from 270-MHz proton magnetic resonance[J].J Am Chem Soc,1977,99:2768-2774.
  • 10Barna JCJ,Williams DH.The structure and mode of action of glycopeptides antibiotics of the vancomycin group[J].Ann Rev Microbi,1984,38:339-357.

共引文献4

同被引文献17

引证文献2

二级引证文献3

化学试剂
2012年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部