摘要
在线红外法是一种通过监测反应体系中各组分浓度变化,直观体现反应历程的监测方法。具有无需取样,灵敏度高,时效性强,应用范围广泛等优点。在N-羟基琥珀酰亚胺酯的合成中采用在线傅里叶红外法,通过实时直观的反应进程,成功克服了实验中的困难,并且有利于进一步的条件优化。所得一系列产物的结构均经过1HNMR确证。
In situ Fourier transform infrared is a method that reflects real-time reaction process by monitoring the concen- tration of every component. It has the advantages of non-man- ual sampling,high sensitivity and wide application range. We have adopted in situ Fourier transform infrared(FTIR) in the synthesis of N-hyroxysuccinimide esters. Not only did we get the desired results, but also accumulate important data for the subsequent optimization of reaction conditions. The structure was confirmed by 1 HNMR.
出处
《化学试剂》
CAS
CSCD
北大核心
2012年第11期1038-1040,共3页
Chemical Reagents
基金
国家"十一五"重大专项关键技术--创新高效合成项目(2009ZX09501-006)
国家"十一五"重大专项化药合成平台资助项目(2009ZX09301-003-1-1)