重庆地区居民血清补体3、高敏C反应蛋白与代谢综合征的相关性比较

Association of serum complement 3 and high sensitive C-reactive protein with metabolic syndrome in Chongqing region residents

目的比较血清补体3(C3)、高敏C反应蛋白(hsC-RP)与MS及其组分的相关性。方法纳入20岁以上的社区人群700名,测量身高、体重、WC、血压,测定C3、hsC-RP及血脂等。采用2005年IDF的MS诊断标准。结果 C3和hsC-RP水平随着MS组分数增加而升高,C3与各代谢指标的相关性均强于hsC-RP;高C3、高hsC-RP人群发生MS的风险均增加,OR值分别为3.97(P<0.01)和1.83(P<0.05)。结论 C3和hsC-RP均是MS的风险因子,其中C3对于MS的风险度高于hsC-RP。

Objective To compare the association of serum complement 3 （C3） versus high sensitive C-reactive protein （hsC-RP） with metabolic syndrome （MS）. Methods The 700 community adults aged above 20 years were enrolled. Weight, height, waist circumference, and blood pressure of the subjects were recorded. C3, hsC-RP, and serum lipids were measured. MS was defined according to the 2005 IDF criteria. Results Both C3 and hsC-RP increased significantly along as the number of MS components in- creased. The correlation between C3 and every biochemical marker of metabolism was stronger than that of hsC-RP. The subjects with high C3 and hsC-RP were more likely to be involved in MS （C3, 0R=3. 97,P 〈0. 01; hsC-RP, OR=1. 83, P〈0.05）. Conclusion Both C3 and hsC-RP are highly related to MS, and C3 is more closely correlated with MS than hsC-RP.