雷公藤多甙对格林-巴利综合征患者白细胞介素6的影响

Effect of Tripterygium Polyglycoside on Interleukin-6 in Patients with Guillain'Barre Syndrome

目的：探讨白细胞介素6（IL-6）在格林-巴利综合征（GBS）发病中的作用及免疫抑制性药物（雷公藤多甙）对其的影响。方法：按Asbury标准选择GBS患者43例，以分层随机原则分为2组，分别用肾上腺皮质类固醇（对照组）和雷公藤多甙（治疗组）治疗，并取静脉血和脑脊液配对标本2ml，用双抗体夹心ELISA法测定IL－6。结果：（1）治疗前GBS患者血清、脑脊液中IL－6测定水平明显高于正常值；（2）治疗前GBS患者脑脊液中IL-6与病情严重程度分级相关密切；（3）治疗后两组临床症状均有不同程度的改善，而治疗组优于对照组（P＜0．05），血清IL－6降低的程度亦是治疗组明显（P＜0.05）。结论：脑脊液中IL－6可作为GBS病情严重程度判断的指标之一。雷公藤多甙抑制脑脊液患者的异常免疫应答优于肾上腺皮质类固醇。

To study the action of interleukin-6(IL-6) in pathogenesis and effect of patients with GuillainBarre syndrome (GBS). Methods: Forty-three patients of GBS were selected according to Asbury's standard and divided into two groups on layer randomize principle, they were treated with adrena1 corticosteroid and Tripterygium polyglycoside (TP) respectively. Serum and cerebrospinal fluid (CSF) content of IL-6 were measured by double antibody sandwich ELISA method. Results: (1)The serum and CSF content of IL-6 in GBS group was higher than those in the normal control group significantly; (2) There was Positive correlation between CSF IL-6 and clinical severity (P <0.01 ) before treatment; (3)After treatment the clinical symptoms were improved in both groups, but the TP treated group showed better effect than the control group in improv ing symptoms and lowering serum IL-6 level (P <0.05). Conclusion: CSF level of IL-6 could be taken as one of the criteria for severity evaluation of patient's condition. TP is superior in suppressing abnormal immune reaction to adrenal corticosteroid in GBS patients.