中西医结合治疗早期糖尿病肾病的临床观察

Clinical Study on Treatment of Incipient Diabetic Nephropathy by Integrated Traditional Chinese and Western Medicine

目的：探讨中西医结合治疗早期糖尿病肾病的疗效。方法：100例患者按随机原则分为两组（各50例），治疗组在采用西药有效控制血糖水平的基础上加用具有益气养阴、活血化瘀功效的中药降糖健肾灵胶囊治疗；对照组则采用单纯西药治疗，两组均治疗3个月，并同时观察两组治疗前后症状、体征及实验室相关指标。结果：总有效率治疗组为90％，对照组为58％，两组比较有显著性差异（P＜0．05）。24h尿白蛋白排泄量，血糖，尿微量白蛋白，血、尿β2-微球蛋白及血脂，血液流变学等指标治疗组治疗后均较治疗前有显著改善（P＜0．05或P＜0．01）。结论：中西医结合治疗早期糖尿病肾病疗效明显优于单纯西药治疗。

To explore the curative effect of integrated traditional Chinese and western medicine (TCMWM) on incipient diabetic nephropathy (DN). Methods: One hundred patients with incipient DN were randomly divided into two groups, the treatment group (50 cases) was treated with TCM-WM therapy, which was carried out by using Jiangtang Janshenling (JTJSL) capsule, a Chinese preparation for supplementing Qi and nourishing Yin, on the basis of controlling blood glucose with western medicine effectively. The 50 patients in the control group were treated with western medicine alone. The course of treatment was three months.Changes of symptoms, signs, and related laboratory parameters were observed before and after treatment. Results: The total effective rate in the treatment group was 90 % while that in the control group was 58 %, the difference between two groups was significant (P<0.05). The related parameters including 24 hours urinary albumin excretion, blood sugar, microalbuminuria, blood and urine β2-microglobulin, blood lipids, and hemorrheology levels were all improved after treatment in the treatment group (P <0. 05 or P <0. 01). Conclusion: The curative effect of TCM-WM was better than that of western medicine alone in treating incipient DN.