内外双囊扩张器注药加速组织扩张的实验研究

Ehancement of tissue expansion in guinea pig by local delivery of chemical agents using a new type expander

目的 探索加速组织扩张速度、提高扩张皮瓣质量的新方法。方法 我们采用自行研制的带导药系统的内外双囊扩张器 (下简称双囊扩张器 ) ,并应用抗收缩剂罂粟碱 ,以豚鼠为实验动物与传统的扩张方法对比。结果 双囊扩张器能有效地将药物导入到扩张囊周围的组织中发挥药理作用 ,使扩张后的皮瓣血流量较常规扩张组显著提高 ,成活长度、长宽比例也明显增加 ,回缩率明显降低 ,表皮明显增厚 ,包膜较其他各组明显变薄 ,真皮在各扩张组和未扩张组相比无明显变化 ,但肉膜层扩张组较未扩张组明显变薄。

Objective To search for the new method to increase the rate of tissue expansion. Methods A new type of double lumen expander was buried in the back of guinea pig. Through the expander chemical agents (papaverine) were delivered. Results The new expander could effectively deliver chemical agents. In comparison with the control group, the blood flow, survival length and the length to width ratio of the expanded flap in the experimental group increased statistically. The immediate retraction ratio of the flap decreased significantly. The epidermis was thicker while the dermis was not significant different from the control. The panniculus carnosus was significant thinner in the expanded group than the unexpanded group. The deep connective tissue was statistically thinner in the group using the new type expander. Conclusion The new type of expansion method could accelerate tissue expansion rate and improve the quality of expanded skin and flap.