贝前列素钠对老年下肢动脉粥样硬化疾病的临床疗效

Therapeutic effects of the beraprost sodium in elderly patients with lower extremity atherosclerotic disease

目的:探讨贝前列素钠对老年下肢动脉粥样硬化疾病的临床疗效。方法:将52例老年下肢动脉粥样硬化疾病引起的间歇性跛行患者随机分为常规治疗组和贝前列素钠组,治疗3个月后,分别检测2组踝臂指数(ABI)、6min步行试验(6-MWT),无痛行走距离、高敏C反应蛋白(HsCRP)的变化。结果:常规治疗能改善老年下肢动脉粥样硬化疾病患者6-MWT和无痛行走距离,降低HsCRP的表达(P<0.05),但对ABI影响不大(P>0.05)。而贝前列素钠能进一步提高患者的无痛行走距离,降低HsCRP的表达(P<0.05)。结论:贝前列素钠可以进一步改善老年下肢动脉粥样硬化疾病患者间歇性跛行的症状,并降低HsCRP的表达。

OBJECTIVE To study the therapeutic effects of the beraprost sodium in elderly patients with lower extremity atherosclerotic disease.METHODS 52 elderly cases with lower extremity atherosclerotic disease were divided to conventional treatment group and beraprost sodium group.After these patients were treated for 3 months,ankle-brachial index（ABI）,6 minutes walk test（6-MWT）,walking distance without pain and High-sensitivity C-reactive protein（HsCRP） were detected.RESULTS Walking distance in 6-MWT and walking distance without pain were increased significantly（P0.05）.And HsCRP was also decreased significantly（P0.05）.But ABI was not changed significantly（P0.05）.Compared with conventional treatment,in the patients who treated with beraprost sodium,walking distance without pain was further increased significantly and HsCRP was also decreased significantly（P0.05）.CONCLUSION After treated with beraprost sodium for 3 months,intermittent claudication in the patients with lower extremity atherosclerotic disease could be further ameliorated,and HsCRP could be decreased too.