中药导入气流弥散法对溃疡性结肠炎患者食物不耐受状态的影响

Effect of Chinese Medicine into the Gas Stream Diffusion Method on the Food Intolerance State of Patients with Ulcerative Colitis

目的观察中药导入气流弥散法对溃疡性结肠炎(UC)的临床疗效及患者食物不耐受(FI)状态的影响。方法 54例UC患者随机分为试验组和对照组各27例,试验组采用中药导入气流弥散法给予芪黄肠康液200ml,每天1次;对照组给予柳氮磺胺吡啶片1.0g口服,每天4次;1个月为1个疗程,连续治疗3疗程。于治疗前、治疗后1个月、3个月进行临床症状评分,于治疗前后进行FI血清特异性IgG抗体检测、参考Baron's分级进行肠镜下炎症程度评分、Southerland疾病活动指数(DAI)评分。结果试验组和对照组总有效率分别为85.19%、76.00%,差异无统计学意义(P>0.05)。与治疗前比较,两组患者治疗后1个月、3个月腹泻,脓血便、腹痛积分均显著下降(P<0.05);治疗后3个月试验组各项症状积分显著低于对照组(P<0.05)。与治疗前比较,治疗后试验组患者FI血清特异性IgG抗体检测阳性率显著降低(P<0.05)。两组患者治疗前后比较Baron’s及SoutherlandDAI评分差异均有统计学意义(P<0.05)。结论中药导入气流弥散法治疗UC疗效确切,且可有效调整患者FI状态。

Objective To observe the efficacy and effect of Chinese medicine into the gas stream diffusion method on the food intolerance （FI） state of patients with ulcerative colitis （UC）. Methods Fifty-four UC patients were randomized into trail group and control group, with 27 in each. The trail group was given Chinese medicine into the gas stream diffusion method with 200ml of Qihuang Changkang Liquid [liquid of huangqi （Radix Astragali）, huanglian （Rhizoma Coptidis） and huangbo （Cortex Phellodendri Chinensis） for UC], once daily. The control group was given 1.0g of sulfasalazine tablets, 4 times daily. One treatment course lasted for one month and the treatment lasted for 3 courses. The clinical symptoms were scored before treatment and after 1 month and 3 months of treatment respectively. FI serum specific IgG antibody was detected, inflammation degree in the colonoscopy was scored according to Baron＇s classification and the Southerland disease activity index （DAD was scored before and after treatment. Results The total effective rate of the trail group and control group was 85.19% and 76. 00% respectively, with no significant difference between groups （P〈0.05）. The scores of diarrhea, mucus, blood and pus and abdominal pain were significantly decreased in both groups after 1 month and 3 months of treatment （P〈0.05）. The symptom score in the trail group were significantly lower than those in the control group after 3 months of treatment （P〈0.05）. The positive rate of FI serum specific IgG antibody was significantly decreased in the trail group after treatment （P〈0.05）. The difference in Baron＇s scores and Southerland DAI scores before and after treatment was significant in both groups （P〈0.05）. Conclusion Chinese medicine into the gas stream diffusion method is effective for UC and could effectively regulate the food in- tolerance state of patients.