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胆酸-萘酰亚胺偶合物的合成与表征

Synthesis and characterization of cholic acid-naphthalimide conjugates
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摘要 1,3-丙二胺或1,2-乙二胺的一端氨基通过单氨基保护,未保护的氨基和1,8-萘二甲酸酐发生亲核取代反应,得到新化合物3;化合物3在盐酸的乙醇溶液作用下脱去保护基,得到化合物4;通过N,N-羰基二咪唑的缩合作用,化合物4和胆酸/脱氧胆酸反应,经过后处理得到胆酸-萘酰亚胺类衍生物5。所得到的化合物结构均经过1H NMR、13C NMR、ESI-MS、熔点测定等手段确认。 Through the protection of the diamine＇ s one amino end, the other side of the amino was reacted with 1 ,8-naphthalic anhydride by nucleophilie substitution, and then novel compounds 3 were obtained. Under the effect of hydrochloric acid ,compounds 3 were converted to compounds 4. By the condensation of N,N-carbonyldiimidazole, compounds 4 reacted with cholic acid or deoxy- cholic acid. After post-processing ,cholic acid-naphthalimide conjugates 5 were obtained. Their structures were characterized by I H NMR,ESI-MS and melting points.
作者 马金飞 陈瑨 霍萃萌 代本才 张豫黎 赵永德
机构地区 河南大学化学化工学院 河南省科学院化学研究所
出处 《化学研究与应用》 CAS CSCD 北大核心 2012年第11期1696-1699,共4页 Chemical Research and Application
关键词 胆酸 萘酰亚胺 合成 抗肿瘤 cholic acid naphthalimide synthesis anti-tumor
分类号 O629.22 [理学—有机化学]
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参考文献12

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化学研究与应用
2012年 第11期

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