摘要
目的:对非甾体抗炎药对女性生育的影响进行循证评价。方法:计算机检索Pubmed、Cochrane图书馆、EMBase、SCI、中国期刊全文数据库等,全面收集相关文献,并应用循证医学的方法,对证据进行分类评价。结果:共检索到8个非甾体抗炎药,结果均表明其对女性生育有可逆性的抑制作用,其中布洛芬、美洛昔康为A级,吲哚美辛、罗非昔布为B级,依托昔布、双氯芬酸、吡罗昔康、萘普生为C级。结论:非甾体抗炎药对女性生育有可逆性的抑制作用,有生育计划的女性应尽量避免非甾体抗炎药的应用。
OBJECTIVE：To conduct evidence-based evaluation for the influence of NSAIDs on female fertility.METHODS：We searched Pubmed,Cochrane laboratory,EMbase,SCI,CNKI,collect relevant literature,classify and evaluate the evidence by the methods of evidence-based medicine.RESULTS：A total of 8 NSAIDs were collected.The current evidence revealed that NSAIDs could inhibit ovulation in female reversibly.Ibuprofen and meloxicam were A class,indometacin and rofecoxib were B class and etoricoxib,diclofenac,piroxicam and naproxen were C class.CONCLUSION：NSAIDs could inhibit ovulation in female reversibly,and women willing for a baby should avoid NSAIDs.
出处
《中国药房》
CAS
CSCD
2012年第44期4201-4204,共4页
China Pharmacy
