生殖支原体感染和HIV感染相关性的Meta分析

Correlation between Mycoplasma Genitalium and HIV Infection:A Meta-Analysis

目的系统评价生殖支原体感染和HIV感染之间的相关性。方法计算机检索MEDLINE、ScienceDirect、EMbase、WanFang Data、CNKI数据库,收集有关生殖支原体和HIV感染相关性的独立队列研究、病例-对照研究以及横断面研究,并追溯所获文献的参考文献,检索时限截至2012年3月。按纳入和排除标准筛选文献、提取资料和评价质量后,采用RevMan 4.2及SAS 9.1.3进行统计分析。结果最终纳入19个研究,共3 430例HIV感染人群和7 656例对照人群。Meta分析结果显示,HIV感染人群中生殖支原体检出率明显高于对照人群差异有统计学意义[OR=2.34,95%CI(1.68,3.28),P<0.000 01]。亚组分析和敏感性分析结果同上述结果一致。结论生殖支原体感染和HIV感染之间存在密切关联,但具体机制仍待进一步研究。受纳入研究质量和数量所限,上述结论尚需今后开展更多高质量的研究加以验证和更新。

Objective To evaluate the correlation between mycoplasma genitalium and HIV infection. Meth- ods Databases including MEDLINE, ScienceDirect, EMbase, WanFang Data, and CNKI were searched from inception to March 2012, so as to identify the independent cohort studies, case-control studies and cross-sectional studies. Moreover, the references of relevant studies were also retrieved. According to the inclusion and exclusion criteria, the studies were screened, the data were extracted, and the methodological quality of the included studies was assessed. Then meta-analysis was performed using RevMan 4.2 and SAS 9.1.3 softwares. Results A total of 19 studies were included, including 3 430 HIV infected patients and 7 656 controlled participants. The results of meta-analyses showed that the HIV infection group was more likely to infect mycoplasma genitalium than the control group （OR=2.34, 95%CI 1.68 to 3.28, P〈0.000 01）. The same results were found in both subgroup and sensitivity analyses. Conclusion Mycoplasma genitaliuman infection is closely related to HIV infection. However, detailed pathogenesis is still unknown. Due to the limited quality and quantity of the included studies, more high-quality studies are needed to prove the above.