氨氯地平阿托伐他汀片联合舒心降脂片治疗高血压伴血脂异常

Amlodipine and Atorvastatin Combined with Shuxin Jianzhi Tablets for Treatment of Hypertension with Dyslipidemia

目的:探讨氨氯地平阿托伐他汀片联合舒心降脂片治疗高血压伴血脂异常的临床疗效。方法:将110例高血压伴血脂异常患者随机分为治疗组57例和对照组53例,均历2周的洗脱期,对照组给予舒心降脂片,4片/次,3次/d。治疗组加用氨氯地平阿托伐他汀片(多达一,5 mg/10 mg)1次/d,疗程24周。观察用药前后血脂、血压变化情况及心血管主要不良事件发生率。结果:治疗组血压控制的有效率明显高于对照组(P<0.05);两组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平较治疗前有显著改善,治疗组改善优于对照组(P<0.05);治疗组心血管主要不良事件发生率8.77%,对照组18.86%。结论:氨氯地平阿托伐他汀片联合舒心降脂片能有效控制高血压伴血脂异常患者血压,能显著改善血脂水平,是一种有效、安全的用药方案。

Objective： To investigate the clinical efficacy of amlodipine and atorvastatin combined with Shuxin Jianzhi tables on treatment of hypertension with dyslipidemia. Method： One hundred and ten hypertensive patients with abnormal lipid were randomly divided into two groups, 58 in the control group and 57 in the treatment group, All patients were experienced a two-week washout period, the control group was given with Shuxin Jianzhi tables, 4 tablets/time, tid; the treatment group was given amlodipine and atorvastatin （Duodayi, 5 mg： 10 mg） once daily for 24 weeks. Changes in blood lipids, blood pressure and cardiovascular adverse event before and after treatment were observed. Result： The blood pressure in the treatment group was more efficient compared with that in the control group （P 〈 0. 05 ）. The level of total cholesterol （TC）, triglyceride （TG） , low density lipoprotein cholesterol （LDL-C） and high density lipoprotein cholesterol （HDL-C） were significant improved in the two groups, the treatment group＇s improvement was better than that in the control group （P 〈 0.05） ; The adverse event rate in the treatment group was 8.77%, and that in the control group was 18.86%. Conclusion： Amlodipine and atorvastatin combined with Shuxin Jianzhi tablets was an effective and safe medication program. It can effectively control blood pressure with hypertension and dyslipidemia, can significantly improve the blood lipid levels.