肺心胶囊治疗肺心病患者60例

Feixin Capsules in Treatment of 60 Patients with Pulmonary Heart Disease

目的:探讨肺心胶囊对慢性肺源性心脏病(CPHD)患者的治疗效果及作用机制。方法:将120例患者随机分为治疗组和对照组,每组60例,两组均给予西医常规治疗,治疗组在此基础上以肺心胶囊口服,每次4粒,每日3次,2个月后观察两组患者的主要症状、体征及并发症,测定患者的血气分析及血液流变学指标。结果:治疗组总有效率91.67%,显著优于对照组80.00%(P<0.05);治疗后两组患者主要症状体征消失或减轻,但治疗组改善明显优于对照组(P<0.01或P<0.05);治疗后两组患者氧分压(PaO2)均提高,CO2分压(PaCO2)均降低,治疗组在改善缺O2、纠正CO2潴留等方面均优于对照组(P<0.01或P<0.05);两组的血液黏度、血浆黏度及红细胞压积与治疗前比较均有下降(P<0.01或P<0.05),治疗组改善明显优于对照组(P<0.05)。结论:肺心胶囊治疗CPHD效果确切,临床应用安全,不良反应少,值得临床推广应用。

Objective： To study the effect and the mechanism of Feixin capsules on patients of chronic pulmonary heart disease （CPHD）. Method： One hundred and twenty patients with CPHD were randomly divided into two groups, the control group and the treatment group, 60 cases in each group. The control group was given the conventional therapy of western medicine alone. The treatment group was treated based on conventional therapy of western medicine and combined with Feixin capsules （4 capsules, tid）. Before the treatment and two months after the treatment, typical symptoms, signs and complications were observed, and hemorheo!ogical parameters and blood gas analysis were examined. Result： The effective rates in the control group was 80% and 91.67% in the treatment group with significant difference （P 〈 0.05）. The results showed that the treatment group was better than the control group in improving and removing clinical symptoms and physical signs （P 〈 0.01 or P 〈 0.05）. PaCO2 and PaO2 of the two groups were decreased and those after the treatment were increased, and the differences were statistically significant in the same group （P 〈0. 01 or P 〈0.05）. After treatment, the differences of PaC02 and PaO2 were statistically significant between the two groups （P 〈 0.05 ）. The blood viscosity, plasma viscosity and hematocrit in two groups dropped after treatment, and the differences were statistically significant （P 〈 0.01or P 〈 0.05 ）. The differences of the blood viscosity, plasma viscosity and hematocrit were statistically significant between the two groups after treatment （ P 〈 0. 05 ）. Conclusion ： The efficacy of Feixin capsules for treatment of CPHD is good, it is safe with less adverse reaction. It is worthy for popularizing clinical application.