糖尿病肾病发病机制研究进展

Overview of Current Researches on Pathogenetic Mechanisms of Diabetic Nephropathy

对糖尿病肾病发病机制的研究进展进行文献整理和分析。通过检索PubMed数据库查阅有关糖尿病肾病作用机制的文献,对近年来国外有关糖尿病肾病发病机制的研究进行了整理和分析。糖尿病肾病的发病机制与多种因素密切相关,包括糖代谢紊乱:[糖基化终末产物(AGEs)的生成、多元醇通络的活化、蛋白激酶C的激活、糖基化终末产物的积聚]、血流动力学异常、氧化应激、细胞因子(转化生长因子、血管内皮生长因子、肿瘤坏死因子α)参与及遗传因素等。近年来诸多学者对糖尿病肾病的发病机制进行的研究已取得了一定的进展,进一步研究本病的发病机制对于寻找有效的防治方法具有重要意义。

Diabetic nephropathies （DN） is the most common chronic complications of diabetes mellitus （DM）, and is the leading cause of end-stage renal disease （ESRD） either. There are a lot of pathogentic mechanisms can contribute to the development of the diaease, such as sugar metabolism disorders, hemodynamic dysfunctions, lipid metabolism disorders, cytokines, oxidatives stress mechanisms and genetic susceptibility etc. These pathogentic mechanisms will be overviewed as follows.