围产期感染与新生儿脑损伤

Perinatal infection and neonatal brain injury

感染、炎症是新生儿脑损伤的重要因素。细菌性感染可引起羊膜绒毛膜炎,其与胎儿及新生儿脑损伤有密切关系。母体感染产生的细胞因子可能导致胎儿神经系统发育障碍。文章重点阐述围产期常见的细菌性感染及其与新生儿脑损伤的关系、发病机制以及脑损伤的诊断和管理。

Infection and inflammatory is important factor for fetal brain damage.Maternal infection may induce chorioamnionitis which is related to fetal and newborn baby brain damage.At same time,the fetal inflammatory response syndrome induced by uterine cavity infection can lead to abnormal neurodevelopment.Here will focus on the relation between common infection in pregnancy and brain damage,the physiology,diagnosis and administration.