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IL-33与免疫细胞的关系 被引量：5

Summarize the relationship between IL-33 and immune cells
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摘要 IL-33是IL-1家族的新成员，在炎性刺激后由多种细胞表达IL-33，并且在细胞溶解过程中释放。IL-33的膜表面受体包括ST2和IL-1受体辅佐蛋白，机体广泛表达ST2，尤其是在Th2型细胞和肥大细胞等免疫细胞中。IL-33通过结合免疫细胞膜表面的ST2将活化信号传递到胞内，经过一系列的信号传递，引起IL-5等免疫因子的释放，起到调节免疫应答等功能。 Interleukin-33 （IL-33）, a newly described member of it IL-1 family, is expressed by many cell types following proinflammatory stimulation and it is thought to be released by cell lysis. The IL-33 receptor, consisting of-ST2 and IL-1 receptor accessory protein, is also widely expressed, particularly by T helper 2 （TH2） cells and mast ceils. IL-33 binds to its receptor and transduces signals into cells： After a series of signal transduetion, the activated cell releases IL-5 and other immune factors. Therefore, IL-33 plays a role in the regulation of the immune responses.
作者 徐汉杰 赵卫东
机构地区 安徽医科大学附属省立医院妇产科
出处 《国际免疫学杂志》 CAS 2012年第6期440-444,共5页 International Journal of Immunology
基金 安徽省科技攻关计划项fit（08010302101）
关键词 IL-33 ST2 TH2细胞 肥大细胞 Interleukin-33 ST2 Th2 Cell Mast Cells
分类号 R392 [医药卫生—免疫学]
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参考文献28

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同被引文献58

  • 1韩聚强,任永强,曹建彪.肥大细胞与肝炎病毒相关肝病研究进展[J].中华临床医师杂志（电子版）,2011,5(18):5410-5411. 被引量：4
  • 2Schmitz J , Owyang A, Oldham E , et al. IL-33, an interleukin-l-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines[J]. Immunity, 2005, 23(5): 479-490.
  • 3Saluja R, Khan M, Church MK, et al. The role of IL-33 and mast cells in allergy and inflammation[J]. Clin Transl Allergy, 2015, 5: 33.
  • 4Ni Y, Tao L, Chen C, et al. The deubiquitinase USPI7 regulates the stability and nuclear function of IL-33[J]. Int J Mol Sci, 2015, 16(11): 27956-27966.
  • 5Li PP, Zhang XM, Yuan D, et al. Decreased expression of IL-33 in immune thrombocytopenia[J]. Int Immunopharmacol, 2015, 28(1): 420-424.
  • 6Matta BM, Tumquist HR. Expansion of regulatory T cells in vitro and in vivo by IL-33[J]. Methods Mol Biol, 2016, 1371: 29-41.
  • 7Yasuda K, Muto T, Kawagoe T, et al. Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice[J]. Proc Natl Acad Sci USA, 2012, 109(9): 3451-3456.
  • 8Zhu XY, Yao LT, Zhao L, et al. Increased levels of interleukin-33 associated with bone erosion and interstitial lung diseases in patients with rheumatoid arthritis[J]. Cytokine, 2012, 58(1): 6-9.
  • 9Latiano A, Palmieri O, Pastorelli L, et al. Associations between genetic polymorphisms in IL-33, IL1R1 and risk for inflammatory bowel disease[J]. PLoS One, 2013, 8(4): e62144.
  • 10López Mejías R, Genre F, Remuzgo Martínez S, et al. Protective role of the interleukin 33 rs3939286 gene polymorphism in the development of subclinical atherosclerosis in rheumatoid arthritis patients[J]. PLoS One, 2015, 10(11): e0143153.

引证文献5

二级引证文献16

国际免疫学杂志
2012年 第6期

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