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CD4^＋CD25^＋调节性T细胞防治移植物抗宿主病的研究进展 被引量：2

Research progress of CD4^＋ CD25^＋ regulatory T cells for the prevention and treatment of GVHD
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摘要 异基因造血干细胞移植是目前治疗白血病、淋巴瘤等恶性血液疾病的有效手段，但是其疗效却受到了移植后发生的移植物抗宿主病的制约与限制。近年来，随着对CD4^＋CD25^＋调节性T细胞（Treg）研究的深入，人们发现这一T细胞亚群不仅在维持免疫自稳和抑制异体免疫应答方面具有重要作用，并且对于预防与治疗移植物抗宿主病也有一定的潜力。 However allo-hematopoietie stem cell transplantation is the crucial treatment of hematologic malignant diseases sueh as Leukemia and lymphoma, the curative effeet of HSCT is hampered by the ineidenee of GVHD after transplantation. In recent years, with the development of CD4^＋ CD25^＋ regulatory T cells study, researchers have realized this T cell subset not only play an essential role in maintenance of immune homeostasis and inhibition of allograft immune response, but for the prevention and treatment of GVHD also has certain po- tential. This article foeuses on the biological features of regulatory T eells and the research development of it for prevention and treatment of GVI-ID.
作者 叶盛 陈兵 周敏
机构地区 南京大学医学院附属鼓楼医院血液科
出处 《国际免疫学杂志》 CAS 2012年第6期461-465,共5页 International Journal of Immunology
关键词 调节性T细胞 移植物抗宿主病 造血干细胞移植 Regulatory T cells Graft-versus-host disease Hematopoietie stem cell transplantation
分类号 R457.7 [医药卫生—治疗学]
  • 相关文献

参考文献31

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二级参考文献20

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共引文献4

同被引文献48

  • 1张颢,龚伟,孟磊,池颖,张浪辉,陈志哲,刘拥军,韩忠朝.脐带间充质干细胞对T细胞的免疫调控研究[J].中国免疫学杂志,2007,23(12):1102-1105. 被引量：15
  • 2任红英,赵钦军,邢文,杨少光,卢士红,任倩,张磊,韩忠朝.脐带间充质干细胞体外分化为有功能的低免疫原性肝细胞样细胞[J].中国医学科学院学报,2010,32(2):190-194. 被引量：24
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引证文献2

二级引证文献6

国际免疫学杂志
2012年 第6期

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