新型蓖麻油基季铵盐的合成及其抑菌性能

Synthesis and Antitumor Activity of Novel Castor Oil-based Quaternary Ammonium

以蓖麻油酸甲酯为起始原料,与N,N-二甲基-1,3-丙二胺和溴化苄、溴乙烷通过酰胺化反应和季铵化反应生成了新型蓖麻油基季铵盐,其结构经FTIR、1HNMR、13CNMR及ESI-MS进行了确证。采用抑菌圈直径法对目标产物的抑菌性能进行了测试,结果表明,两种季铵盐均有一定的抑菌活性,N,N-二甲基-N-乙基-蓖麻油酸酰胺丙基溴化铵的抑菌活性略强于N,N-二甲基-N-苄基-蓖麻油酸酰胺丙基溴化铵。

Two kinds of novel castor oil-based quaternary ammonium were synthesized from the starting material of methyl ricinoleate by amidation reaction and quaternization reaction. Their structures were characterized by means of FTIR, 1HNMR, 13 CNMR and ESI（MS）. The bactericidal activity of the novel castor oil-based quaternary ammonium salts was evaluated by inhibitory zone diameters against E. coli and S. aureus. It is found that they have antibacterial activity. The antibacterial activity of N, N- dimethyl-N-ethyl-castor oil acid amide propyl bromide is stronger than that of N-benzyl-N,N-dimethyl- castor oil acid amide propyl bromide.