米索前列醇舌下含服用于足月妊娠引产的安全性分析

Assessing the Saftety of Misoprostol in Induction of Term Labor-A Rertrospective Analysis

目的 :探讨米索前列醇用于足月妊娠引产的安全性。方法 :回顾性分析了 2 16例使用米索前列醇引产和 2 0 0例使用缩宫素引产的足月妊娠产妇的临床资料。结果 :米索组产程中出现不协调宫缩 6 3例 ,占 2 9.2 % ,过频宫缩 43例 ,占 19.9% ,而缩宫素未出现异常宫缩。两组羊水混浊发生率分别为 2 1.8%和 14.5 % ,P<0 .0 1,差异有显著性。两组 CST(+)发生率分别为 12 .0 %和 6 .0 % ,P<0 .0 5 ,差异有显著性。剖宫产原因中 ,胎儿宫内窘迫均为两组主要手术指征 ,米索组 30例 ,占 78.9% ,缩宫素 17例 ,占 5 4.8% ,P<0 .0 5 ,差异有显著性 ,提示 :米索前列醇用于足月妊娠引产 。

Objective:To assess the safety of misoprostol in labor induction of term pregnancy.Methods:Retrospective analysis of 416 clinical records of full term pregnant women.216 cases were given misoprostol and 200 cases were administerd oxytocin.Results:During the course of labor,the uterine contraction were incoordinatly in 63 cases (29.2%) and 43 cases(19.9%)were with superstimalation in misoprostol group,but none was abnormal uterine contraction in oxytocin group.The rate of meconium was 21.8% in misoprostol group and 14.5% in oxytocin group ( P <0.01).The rate of CST(+) in the two groups were 12.0% and 6.0% respectively( P <0.05).Intrauterine asphyxia was the mainly reason of caesarean section in both groups.But there were 30 cases(78.9%)in misoprostol group and 17 cases(54.8%) in oxytocin group,there were significant difference( P <0.05).Conclusion:Application of misoprstol in induction of term labor engaged in potential risk.