卵巢上皮性癌142例治疗与预后因素分析

Investingation of the Rusluts of Treatment and Prognosis of 142 Cases of Epithelial Cancer Ovarian

目的 :对卵巢上皮性癌的治疗与预后进行分析。方法 :对 1983年 1月至 1993年 12月在瑞金医院治疗的 142例卵巢上皮性癌进行回顾分析 ,所有病人均经手术后病理诊断并按 FIGO(1985 )标准进行临床分期 ,术后化疗以 CAP方案为主 (环磷酰胺、阿霉素、顺氯氨铂 ) ,采用 SURVCAL C软件统计 ,对资料进行单因素及多因素 COX逐步回归分析确定影响患者预后的因素。结果 :3年、5年、10年的生存率分别为 : 期 97.92 %、97.92 %、93.75 % ; 期 81.3%、5 0 %、6 .3% ; 期 34 .2 1%、18.4%、5 .3% ; 期 6 .1%、0 .0 % ,0 .0 % (P<0 .0 0 1)。化疗疗程数 >6比 <6者预后好 (P<0 .0 1)。无残留或残留癌 <2 cm者为 73.13% ,比 >2 cm者预后好 ,为 2 6 .86 % (P<0 .0 1)。结论

WT5”BZ]Objective:[WT5”BZ]Investigation of the rusluts of treatment and prognosis of epithelial ovaian cancer dusing Jan 1983 through Dec.1993.Methods:[WT5”BZ]A Retrospective study of 142 cases of ovarian epithelial carcinoma in Rui Jing hospital from Jan 1983 Dec 1993 is undertaken.All of these cases had postoperative pathological diagnosis and were staged according FIGO staging system 1985.CAP(cyclophosphamide,Adriamgcin,Cisplatin)regimens were the administed postoperatively.COX model was used to evaluate the prognostic factors of the disease at univariate and maltivarivate levels using SUKVCALC software.Results:[WT5”BZ]the 3 year 5 year and 10 year suruival rates of stage I are 97.92%,97.92%,93.75%;and Ⅱ 81.3%,50%,6.3%;Ⅲ 34.21%,18.4%,5.3%,and Ⅳ 6.1%,0.0%,0.0% respectively ( P <0.001).The prognostis of those who had more than 6 courses was better than patients with less than 6 courses of chemotherapy.The suriviral rates of patients with no residual tumor>2cm or residual tumor<2cm are 73.13% and 26.86% respectively( P <0.01).Conclusion:[WT5”BZ]The survival of the epithelial ovarian cances patients is relevant to the presence of residual tumor and number of the courses of postoperative chemotherapy. [WT5”HZ]