摘要
目的 :观察心肌尔康颗粒对病毒性心肌炎的防治作用。方法 :采用小鼠病毒性心肌炎模型及体外抗柯萨奇B3m病毒实验 ,阿霉素致小鼠中毒性心肌炎模型 ,氯化钡、氯仿致心律失常模型 ,蛋清、琼脂致炎模型及心脏血流动力学等试验。结果 :心肌尔康颗粒在体内、外均有抗柯萨奇病毒B3m作用 ,对小鼠病毒性心肌炎和中毒性心肌炎均有防治作用 ,能降低小鼠死亡率及血清LDH ,AST和CK水平 ,改善心电图及心肌的病理性损害 ,以及降低病毒性心肌炎小鼠血清中和抗体和心脏病毒滴度。还有抗心律失常、增强心肌收缩力、抗心肌缺氧、抗炎作用 ,以及能升高大鼠血清IgG水平。结论 :心肌尔康颗粒有抗病毒性及中毒性心肌炎的作用。
Objective: To investigate the inhibitory effect of Xinjierkang(XJEK) granules on virus myocarditis. Methods: Using a model mouse of virus myocarditis induced by coxsackie virus B 3m (CVB 3m )and mouse toxic myocarditis induced by adriamycin,a model of arrhythmia induced by BaCl 2 and CHCl 3, a model of inflammation caused by egg white and agar, along with a dynamic test of cardiac blood flow and an inhibitory test of CVB 3m in vitro. Results: XJEK granules are efficacious in inhibiting CVB 3m both in vitro and in vivo, protecting and curing virus myocarditis and toxic myocarditis in mice, reducing mouse death rate, serum level of LDH, AST and CK, titer of neutralizing antibodies, virus concentration of heart, and improving the abnormal ECG, pathological and ultrastructural damage of myocadium. The granules are also good for anti inflammation, anti myocardial ischemia, anti arrhythmia, as well as for strengthening myocardiac contraction and increasing the serum IgG level. Conclusion: Xinjierkang granules possess an inhibitory effect on virus myocarditis and toxic myocarditis.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2000年第5期293-296,共4页
China Journal of Chinese Materia Medica
基金
安徽省科委研究项目! [皖科计字 ( 1994) 2 10号 ]
