防风色原酮甙类成分的药理活性研究

A Pharmacodynamic Research on Chromone Glucosides of Fangfeng

目的 :观察防风两种色原酮甙类成分升麻甙和 5 O 甲基维斯阿米醇甙的药理作用。方法 :采用酵母致热法、醋酸致痛法、温热致痛法及二甲苯致炎法分别研究了其镇痛、抗炎作用。结果 :升麻甙和 5 O 甲基维斯阿米醇甙可降低大鼠体温 ,使醋酸扭体数减少 ,提高温热痛阀 ,减轻二甲苯引起的耳肿胀 ,对ADP诱导的血小板聚集有明显的抑制作用。结论 :升麻甙和 5 O 甲基维斯阿米醇甙均具有明显的解热、镇痛、抗炎及抗血小板聚集作用。

Objective: To investigate the pharmacological activity of prim-O-glucosylcimifugin and 4'-O-β-D-glucosyl-5-O-methylvisamminol con tained in Fangfeng.Methods: Analgesic, antipyretic and antiinflammatory effects were assessed using the models of yeast-induced rat fever, acetic acidinduced peritoneal pain thermal-pain, and dimethylbenzol-induced mouse ear edema. Results: Prim-O-glucosylcimifugin and 4'-O-β-D-glucosyl-5-O-methylvisamminol could reduce the body temperature of rats in a model of yeast induced fever. Both components could decrease the spasm action induced by peritoneal injection of acetic acid, increase the pain-threshold in a thermal-pain model, relieve the mouse ear edema caused by dimethybenzol and significantly inhibit ADP-induced platelet aggregation. Conclusion: Prim-O-glucosylcimifugin and 4'-O-β-D-glucosyl-5-O-methylvisamminol have significant analgesic, antipyretic, anti-inflammatory and anti-platelet aggregation actions.