摘要
建立了18F-FDG放射化学纯度的分析方法。以丙酮-水(体积比为50∶20)为展开剂,用2%KAlSO4溶液处理的Whatman No.1纸为固定相,18 F-的Rf=0,18 F-FDG的Rf=0.78,方法的相对标准偏差小于1%。本方法简便、快速,适用于18F-FDG注射液的放射化学纯度分析。对放射化学纯度分析方法的不确定度进行了初步评定,本方法的扩展不确定度u=0.199 1,u由合成不确定度uc=0.095 00及包含因子k=2.096而得。
The analytical method of 18F-FDG radiochemical purity was established.The mixed solution of acetone-water（50∶20（V/V）） was used as developing reagent.Whatman No.1 paper pre-processed with 2% KAlSO4 solution was used as stationary phase.The Rf values of 18F-and 18F-FDG are 0 and 0.78,respectively.The relative standard deviation is less than 1%.This method is simple,rapid,and suitable for radiochemical purity analysis of 18F-FDG injection.The uncertainty of analysis method for the radiochemical purity was evaluated.The expanded uncertainty u of this method is 0.199 1,and u is derived from the synthesis uncertainty（uc=0.095 00） and the coverage factor（k=2.096）.
出处
《原子能科学技术》
EI
CAS
CSCD
北大核心
2012年第B09期84-88,共5页
Atomic Energy Science and Technology
