封髓丹颗粒剂抗实验性口腔溃疡的作用

Action of Fengsuidan Granules on Experimental Anti-oral Ulcer

目的 :探讨封髓丹颗粒剂抗口腔溃疡及镇痛抗炎作用。方法 :给动物灌服封髓丹颗粒剂 (0 .5 ,5 .0 ,10 .0g·kg-1)。动物口腔溃疡分别系由皮下注射白色葡萄球菌及石炭酸烧灼而成。应用醋酸扭体法、热板法、二甲苯致耳郭炎症及足肿胀法。结果与结论 :实验数据表明该方药具有抗口腔溃疡作用 ,可加速溃疡面积缩小及愈合 ,并具有镇痛抗炎作用 ,且量效关系规律。

Objective: To explore the anti oral ulcer action, anti inflammatory and analgesic effect of Fengsuidan Granules(FSDG). Methods: FSDG(0.5,5.0,10.0 g·kg -1 ) were administered to experimental animals. The oral ulcer in experimental animals was effected by means of white staphylococcus (sc)and carbolic acid (buming).Results: Such as acetic acid body turning,hot plate, auricle in flammation by dimethylbenzene and foot swelling by egg white were used. Conclusion: Following certain regularities of dose effect relationship, FSDG has anti oral ulcer effect, helps reduce and heal the ulcer and works efficaciously in analgesic and anti inflammatory cases.