肺腺癌及肺鳞癌MRP-mRNA的表达及临床意义

Expression of multidrug resistance associated protein in adenocarcinoma and squamous cell carcinoma of the lung

目的 :观察 3 0例肺癌组织及癌旁肺组织 MRP的表达。方法 :RT- PCR方法。结果 :4 3 .3 3 %的肺癌组织表达 MRP,且 MRP的表达与细胞分化程度有关 ,低分化者 MRP的表达明显高于中高分化者 ( P<0 .0 5 )。腺癌的表达 ( 62 .5 % )高于鳞癌 ( 2 1.4 3 % ,P=0 .0 5 8)。MRP的表达与临床分期无关 ( P=0 .5 11)。结论 :4 3 .3 3 %的肺癌组织表达 MRP。

Objective:To investigate the expression of multidrug resistance associated protein (MRP) in 30 cases with adenocarcinoma and squamous cell carcinoma of the lung. Methods:RT PCR method. Results:Expressed in MRP mRNA was thirteen (43 33%) of the 30 cases examined by tumor biopsies, and its expression was associated with the degree of differentiation and histopathology of the tumor ( P <0 05). but not related to the clinical staging ( P <0 05). Conclusion:Our results suggest that MRP may be implicated drug resistance in adenocarcinoma and squamous cell carcnoma of the lung.